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Thomas C. Rich, Ph.D.

Thomas C. Rich, Ph.D.
Assistant Professor
Phone: 251-460-6039
Fax: 251-460-6798
trich@jaguar1.usouthal.edu

EDUCATION
1996 Ph.D. in Biomedical Engineering, Vanderbilt University, Nashville, TN
   
1990 M.S. in Aerospace Engineering, Georgia Institute of Technology, Atlanta, GA
   
1988 B.A.E. with Honors, Georgia Institute of Technology, Atlanta, GA

ACADEMIC APPOINTMENTS

2005-present Assistant Professor, University of South Alabama College of Medicine, Department of Pharmacology, Mobile, AL
   
2002-2005 Assistant Professor, University of Texas – Houston Medical School, Department of Integrative Biology and Pharmacology, Houston, TX
   
1997-2002 Postdoctoral Fellow, University of Colorado Health Sciences Center, Department of Physiology and Biophysics, Denver, CO
   
1996-1997 Postdoctoral Fellow, National Cardiovascular Center Research Institute, Department of Cardiovascular Dynamics, Osaka, Japan

CURRENT GRANT AWARDS
7/2003-6/2007 American Heart Association Scientist Development Grant, 0335084N, Principal Investigator, 20% effort, Real-time measurement of cGMP signals in single cardiac myocytes, total direct costs $236,364.
   
4/2004-3/2008 National Institutes of Health, R01HL074278, Principal Investigator, 40% effort, Cyclic AMP signaling in cardiac myocytes, total direct costs $775,000.
   
9/2005-8/2010 National Institutes of Health, K02HL081463, Principal Investigator, 75% effort, Modeling β2 receptor activity in a cellular environment, total direct costs $463,875.

PREVIOUS GRANT AWARDS
1/2004-12/2005 Texas Advanced Technology Program, 011618-0106-2003, Principal Investigator, 10% effort, Novel bioassays for measuring cAMP and subsequent desensitization of β2-adrenergic receptors, total direct costs $205,000.

PROFESSIONAL ACTIVITIES

1994-present Biophysical Society
1999 Ad hoc reviewer, Journal of Neuroscience
2003 Ad hoc reviewer, Chemistry and Biology
2004 Ad hoc reviewer, Journal of Biological Chemistry Ad hoc reviewer, R&D Excellence Program for the Kentucky Science and Engineering Foundation
  Ad hoc reviewer, Homeland Security Initiative for the KSEF
2006 Ad hoc reviewer, American Journal of Physiology – Lung
  Ad hoc reviewer, American Journal of Physiology – Cell
  Ad hoc reviewer, Regulatory Peptides
  Discussion Leader, Membrane Anchoring Proteins and Compartmentation of PDE, Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases
  Ad hoc reviewer, R&D Excellence Program for the Kentucky Science and Engineering Foundation
2007 Ad hoc reviewer, American Journal of Physiology – Lung
  Ad hoc reviewer, Journal of General Physiology

USA COLLEGE OF MEDICINE SERVICE
2006-present Distinguished Scientist Seminar Program Committee
2006-present Radiation Safety Committee
2006-present Graduate Student Admissions Committee

INVITED PRESENTATIONS
1996 National Cardiovascular Center Research Institute – Department of Cardiovascular Dynamics, Osaka, Japan
2000 Vanderbilt University – Department of Biomedical Engineering, Nashville, TN
2002 University of Texas Health Science Center at Houston – Department of Ophthalmology and Visual Science, Houston, TX
2003 University of Texas Health Science Center at Houston – Center for Cardiovascular Biology and Atherosclerosis, Houston, TX
  Texas Southern University, Biomedical Research Forum, College of Pharmacy and Health Sciences, Houston, TX
2004 Tulane University, Physics Colloquium, Department of Physics, New Orleans, LA
Thomas Jefferson University, Department of Biochemistry and Molecular Pharmacology, Philadelphia, PA
  Baylor College of Medicine, Graduate Program in Structural and Computational Biology and Molecular Biophysics, Houston, TX
2005 University of Michigan Medical School, Department of Pharmacology, Ann Arbor, MI
  Washington State University, Department of Chemical Engineering and Bioengineering, Pullman, WA
  Rosalind Franklin University of Medicine and Science, Department of Physiology and Biophysics, North Chicago, IL
2006 Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases, Biddeford, ME
  University of South Alabama, Cell Signaling Seminar Series, Mobile, AL
  University of South Alabama, Bioinformatics Seminar Series, Mobile, AL
2007 Experimental Biology Symposium on Imaging Localized cAMP Signaling Dynamics Organized by AKAP Scaffold Proteins and Phosphodiesterases, Washington D.C.

PEER-REVIEWED PUBLICATIONS
  1. Yeola, S.W., T.C. Rich, V.N. Uebele, M.M. Tamkun, D.J. Snyders. 1996. Molecular analysis of a binding site for quinidine in a human cardiac delayed rectifier. Role of S6 in antiarrhythmic drug binding. Circ. Res. 78:1105-1114. [see commentary: Colatsky, T.J. 1996. Circ. Res. 78:1115-1116.]
  2. Rich, T.C., D.J. Snyders. 1998. Evidence for multiple open and inactivated states of the hKv1.5 delayed rectifier. Biophys. J. 75:183-195.
  3. Fagan, K.A., T.C. Rich, S. Tolman, J. Schaack, J.W. Karpen, D.M.F. Cooper. 1999. Adenovirus-mediated expression of an olfactory cyclic nucleotide-gated channel regulates the endogenous Ca2+-inhibitable adenylyl cyclase in C6-2B glioma cells. J. Biol. Chem. 274:12445-12453.
  4. Rich, T.C., K.A. Fagan, H. Nakata, J. Schaack, D.M.F. Cooper, J.W. Karpen. 2000. Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion. J. Gen. Physiol. 116:147-161. [see commentary: Pugh, E.N. 2000. J. Gen. Physiol. 116:143-146.]
  5. Rich, T.C., T.E. Tse, J.G. Rohan, J. Schaack, J.W. Karpen. 2001. In vivo assessment of phosphodiesterase activity using tailored cyclic nucleotide-gated channels as cAMP sensors. J. Gen. Physiol. 118:63-77.
  6. Rich, T.C., K.A. Fagan, T.E. Tse, J. Schaack, D.M.F. Cooper, J.W. Karpen. 2001. A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell. Proc. Natl. Acad. Sci. USA 98:13049-13054. [see commentary: Schwartz, J.H. 2001. Proc. Natl. Acad. Sci. USA 98:13482-13484.]
  7. Rich, T.C., S.W. Yeola, M.M. Tamkun, D.J. Snyders. 2002. Mutations throughout the S6 region of the voltage-gated hKv1.5 channel alter the stability of the activation gate. Am. J. Physiol. 282:C161-C171.
  8. Rich, T.C., J.W. Karpen. 2002. Cyclic AMP sensors in living cells: what signals can they actually measure? Ann. Biomed. Eng. 30:1088-1099.
  9. Brady, J.D., T.C. Rich, X. Le, K. Stafford, L. Lynch, S. McLoud, J.W. Karpen, R.L. Brown, J.P. Martens. 2004 Functional role of lipid rafts in cyclic nucleotide-gated channel activation. Mol. Pharmacol. 65:203-211.
  10. Piggott, L.A., K.A. Hassell, Z. Berkova, A.P. Morris, M. Silberbach, T.C. Rich. 2006. Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments. J. Gen. Physiol. 128:3-14. 4
  11. Rich, T.C., W. Xin, C. Mehats, K.A. Hassell, L.A. Piggott, X. Le, JW. Karpen, and M. Conti. 2007. Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells. Am. J. Physiol. 292:C319-C331.

OTHER PUBLICATIONS
  1. Karpen, J.W., T.C. Rich. 2001. The fourth dimension in cellular signaling. Science 293:2204-2205.
  2. Clark, R.B., T.C. Rich. 2003. Probing the roles of protein kinases in G-protein-coupled receptor desensitization. Mol. Pharmacol. 64:1015-1017.
  3. Karpen, J.W., and T.C. Rich, 2004. Resolution of cAMP signals in three-dimensional microdomains using novel, real-time sensors. Proc. West. Pharmacol. Soc. 47:1-5.
  4. Karpen, J.W., T.C. Rich. 2005. High-resolution measurements of cAMP signals in threedimensional microdomains. Meth. Mol. Biol. 307:15-26.
  5. Rich, T.C., J.W. Karpen. 2005. High-throughput screening of PDE activity in living cells. Meth. Mol. Biol. 307:45-62.

PATENTS
Karpen, J.W., T.C. Rich, D.M.F. Cooper, J. Schaack. 2007. Modified cyclic nucleotide-gated channels. United States Patent # 7166463.

CONFERENCE ABSTRACTS

  1. Rich, T.C., S.N. Yeola, I.A. Blair, S.W. Yeola, D.J. Snyders. 1994. Quaternary quinidine derivatives as a tool to study block of human potassium channels. Biophys. J. 66:143a.
  2. Rich, T.C., D.J. Mays, M.M. Tamkun, D.J. Snyders. 1994. Quinidine block of the human cardiac Kv1.5 channel in inside-out patches. Biophys. J. 66:209a.
  3. Rich, T.C., D.J. Snyders. 1995. Energetics of hKv1.5 gating. Biophys. J. 68:35a.
  4. Snyders, D.J., T.C. Rich, D.J. Mays, M.M. Tamkun, S.W. Yeola. 1996. Involvement of S6 in voltage-dependent gating of hKv1.5 potassium channels. Biophys. J. 70:144a.
  5. Rich, T.C., D.J. Snyders. 1997. Evidence for multiple open states in Kv1.5 gating. Biophys. J. 72:130a.
  6. Rich, T.C., K.A. Fagan, J. Schaack, D.M.F. Cooper, J.W. Karpen. 1999. A localized, singlecell measure of cyclic AMP concentration using cyclic nucleotide-gated channels. J. Gen. Physiol. 114:16a.
  7. Rich, T.C., K.A. Fagan, J. Schaack, D.M.F. Cooper, J.W. Karpen. 2000. Regulation of cAMP within diffusionally-restricted microdomains. Biophys. J. 78:391a.
  8. Rich, T.C. 2000. A model of membrane excitability in cultured GH4 cells. 2000. Biophys. J. 78:218a.5
  9. Rich, T.C., K.A. Fagan, T.E. Tse, J. Schaack, D.M.F. Cooper, J.W. Karpen. 2000. Improved single-cell measurement reveals distinct cAMP signals in different cellular compartments. Mol. Biol. Cell. 11:249a.
  10. Rich, T.C., K.A. Fagan, T.E. Tse, J. Schaack, D.M.F. Cooper, J.W. Karpen. 2001. Measurement of localized, transient cAMP signals in single cells. Biophys. J. 80:345a.
  11. Rich, T.C., K.A. Fagan, T.E. Tse, J. Schaack, D.M.F. Cooper, J.W. Karpen. 2001. The role of phosphodiesterase in shaping cAMP signals near the plasma membrane. Biophys. J. 80:250a.
  12. Rich, T.C., T.E. Tse, J. Schaack, J.W. Karpen. 2001. Resolution of localized cyclic AMP signals using novel, real-time sensors. Circulation. 104:755.
  13. Rich, T.C., J.W. Karpen. 2002. Evaluation of different strategies for measuring cAMP signals. Biophys. J. 82:218a.
  14. Rich, T.C. 2002. Modeling of feedback interactions between MAP kinase and cAMP signaling pathways. Proc. Second Joint EMBS/BMES Conf. 722-723.
  15. Brady, J.D., T.C. Rich, X. Le, K. Stafford, L. Lynch, S. McLoud, F. Muller, U.B. Kaupp, J.W. Karpen, R.L. Brown, J.P. Martens. 2003. Localization of cyclic nucleotide-gated channels to lipid raft microdomains: implications for compartmentalized cAMP signaling. Biophys. J. 84:401a.
  16. Rich T.C., C.W. Dessauer. 2004. Assessment of PDE activity in rat neonatal cardiac myocytes. Biophys. J. 86:229a.
  17. Hassell, K.A., C.W. Dessauer, T.C. Rich. 2004. PDE type 4 regulates basal cAMP levels in cultured vascular smooth muscle cells. Biophys. J. 86:229a.
  18. Piggott, L.A., K.A. Hassell, M. Silberbach, T.C. Rich. 2005. Functional colocalization of particulate guanylyl cyclase and adenovirus-expressed CNG channels. Circulation. 112:II-147.
  19. Rich, T.C., W.K. Xin, C. Mehats, K.A. Hassell, L.A. Piggott, X. Le, J.W. Karpen, and M. Conti. 2006. PKA-mediated stimulation of PDE4 activity in conjunction with diffusional barriers and buffering regulate transient cAMP signals near the plasma membrane of HEK- 293 cells. Biophys. J. 90a.
  20. Xin, W.K. and T.C. Rich. 2006. The roles of phosphodiesterase activity and receptor desensitization in shaping cyclic nucleotide signals. AHA Research Symposium. 64a.
  21. Rich, T.C., S.J. Vayttaden, R.B. Clark, W.K. Xin. 2007. GRK and PDE4 activities underlie sustained suppression of β2 adrenergic signals. Experimental Biology. 236a.
  22. Rich T.C., W.K. Xin, A.L. Britain, J.W. Karpen. 2007. Functional segregation of prostaglandin- and isoproterenol-induced cAMP signals. Experimental Biology. 236a.
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