Strada, Samuel J., Ph.D.

Strada, Samuel J., Ph.D.
Professor
Phone: (251) 460-6041
Fax: (251) 460-6073
sstrada@jaguar1.usouthal.edu

UNDERGRADUATE EDUCATION

1959-1960	Rockhurst College
	Kansas City, Missouri

1960-1964	University of Missouri at Kansas City
	Kansas City, Missouri
	B.Sc. (with Distinction) - Pharmacy

GRADUATE EDUCATION

1964-1966	University of Missouri at Kansas City
	M.Sc. - Pharmacology (Vernon A. Green, Ph.D., Advisor)


1966-1970	Vanderbilt University
	Nashville, Tennessee
	Ph.D. - Pharmacology
	(Fridolin Sulser, M.D., Advisor)

POSTGRADUATE

1970-1972	Laboratory of Preclinical Pharmacology
	National Institutes of Mental Health
	St. Elizabeths Hospital
	Washington,D.C.
	(Erminio Costa, M.D. and Benjamin Weiss, Ph.D, Advisors)

SABBATICAL

1979-1980	University of Dundee Medical Sciences Institute
	Department of Biochemistry, Dundee, Scotland
	(Professor Philip Cohen, Ph.D., Sponsor)

ACADEMIC APPOINTMENTS

11/1993 - Present	Senior Associate Dean, University of South Alabama,
	College of Medicine, Mobile, Alabama
07/1983 - Present	Professor of Pharmacology, University of South Alabama,
	College of Medicine, Mobile, Alabama
07/1983 - 12/1994	Chairman, Department of Pharmacology,
	University of South Alabama, College of Medicine, Mobile, Alabama
02/1992 - 09/1992	Acting Head, Department of Psychiatry,
	University of South Alabama, College of Medicine, Mobile, Alabama
10/1990 - 02/1992	Acting Director, Graduate Program in Basic Medical Sciences,
	University of South Alabama, College of Medicine, Mobile, Alabama
01/1983 - 07/1983	Chairman Designate, Department of Pharmacology,
	University of South Alabama, College of Medicine Mobile, Alabama
09/1981 - 07/1983	Professor of Pharmacology, The University of Texas
	Medical School at Houston, Houston, Texas
01/1982 - 12/1982	Acting Chairman, Department of Pharmacology,
	The University of Texas Medical School at Houston, Houston, Texas
07/1975 - 08/1981	Associate Professor of Pharmacology, The University of Texas
	Medical School at Houston, Department of Pharmacology, Houston, Texas
07/1972 - 07/1975	Assistant Professor, The University of Texas Medical School at Houston,
	Program in Pharmacology, Houston, Texas
08/1972 - 07/1983	Graduate Faculty Member, The University of Texas
	Graduate School of Biomedical Sciences

CONSULTANTSHIPS

01/1984 - 12/ 1986	Consultant in Biology Research,
	Ciba-Geigy Corp.,Pharmaceutical Division, Summit, New Jersey

PROFESSIONAL ORGANIZATIONS

Alabama Academy of Science
American Association for the Advancement of Science
American Society for Pharmacology and Experimental
Therapeutics (ASPET)
Association for Medical School Pharmacology (AMSP)
Association of University Technology Managers
Basic Science Education Forum
Foundation for Advanced Education in the Sciences
International Association of Medical Science Educators
New York Academy of Sciences
Sigma Xi
Society for Neurosciences
Southeastern Pharmacology Society (Lifetime Member)
Tissue Culture Association

HONORS AND AWARDS

UNDERGRADUATE

Academic Achievement Scholarship, Rockhurst College (1959-60)

University of Missouri at Kansas City
American Foundation for Pharmaceutical Education Scholarship (1963-64)
Rho Chi Pharmaceutical Honor Society (1964)
Merck Award for Outstanding Performance in Medicinal Chemistry (1964)
Torch and Scroll Honor Society (1964)
Lehn and Fink Award as Top Pharmacy Student (1964)
Kappa Psi Gold Key and Scholarship Award for Highest GPA in Graduating Class (1964)

GRADUATE
Graduate Trainee Fellowship, National Heart Institute, Summer Trainee in Physiology, Baylor College of Medicine (1965)
Predoctoral Research Fellowship, National Institute of Health (1966-70)

POSTGRADUATE
Staff Fellowship, National Institute of Mental Health (1970-72)
Pharmaceutical Manufacturers Association Foundation Faculty
Development Award in Pharmacology (1974-76)
Senior International Fellowship, John E. Fogarty International Center for Advanced Study in Health Sciences (1979-80)
Faculty Recognition, Honors Convocation: University of South Alabama College of Medicine Graduating Class (1990, 1991)
Best Basic Science Course, 1991, 1993, 1994 graduating class
Elected Faculty Member, 1991, Alpha Omega Alpha Honor Medical Society

ELECTED OFFICES:
Vice-Chairman Southwest Science Forum (Neuroscience Section) (1976-82)
Councilor, Society for Neuroscience (Texas Chapter) (1977-81)
Faculty Senate (School-wide election to represent Full Professors) University of Texas Medical School at Houston (1982-83)
President, Southeastern Pharmacology Society (SEPS) (1985-86)
Graduate Student Advisor, USA Graduate Students in Biomedical Sciences (1985-86;1986-87; 1990-92)
Councilor, Southeastern Pharmacology Society (1987-92)
President, Faculty Assembly, University of South Alabama College of Medicine (1988-89)
Secretary, Association for Medical School Pharmacology Chairs (1990-92)
President, Association for Medical School Pharmacology Chairs (1992-94)

EDITORAL BOARDS

CNS Drug Reviews, Neva Press, (1994-present)

Patient Oriented Problem-Solving (POPS) System in Pharmacology, The Upjohn Company, (1993-1998)

Substance and Alcohol Actions/Misuse (1980-1984)

Second Messengers and Phosphoproteins (1985-1994)

The Journal of Cyclic Nucleotide and Protein Phosphorylation Research (1974-1985)

SERVICE ON NATIONAL GRANT REVIEW PANELS, STUDY SECTIONS, COMMITTEES

Chairman, Registration Committee, Joint Fall Meeting of ASPET & SOT (1978)

Adhoc Committee of Coordinating Board for State of Texas: Texas Southern University Pharmacy School Accreditation Evaluation Committee (1981)

Member, Basic Science Merit Review Board, Veterans Administration (1981-1984)

Adhoc Member, Site Visit Team, NIMH, Neuropsychology Study Section, University of California at Irvine (April, 1982)

Member, Medical College of Pennsylvania National Research Review Board (1982-1985)

Peer Reviewer, Health Sciences Consortium, University of North Carolina, Review of Program Teaching Materials in Pharmacology (1978-83)

Adhoc Member, Site Visit Team, NIHL&B, Program Project, University of Tennessee Health Center in Memphis (May, 1985).

Division of Physiology, Cellular and Molecular Biology, National Science Foundation, Adhoc Reviewer

1986 Otto Krayer Award Committee, ASPET

1990 Abel Award Committee, ASPET; 1991 Abel Award Committee (Chair), ASPET

ASPET Committee on Public Affairs (1987-1994)

Delegate, the United State Pharmacopeial Convention (1987-95)

Member, ASPET Nominating Committee (1995); (1999,alternate)

Member, ASPET Committee on Professional Affairs, Subcommittee on Minorities (1995-98)

Consultant, Academic Program Review--Biological Sciences at University of Arkansas for Medical Sciences, Arkansas Department of Higher Education (1995-96)

Member, LCME Accreditation Team, AAMC/AMA, Tulane University School of Medicine, (January 15-19, 1996)

AMSP Representative, AAMC Council of Academic Societies (1997- )

Member, AAMC Group on Graduate Research, Education and Training (GREAT Group) (1996- )

Chair, External Review Committee, Department of Pharmacology and Toxicology, Medical College of Georgia (October 21-23, 1997)

Member, Nominating Committee, AAMC Council of Academic Societies (1999)

Chair, External Review Committee, Department of Pharmacology and Experimental Therapeutics, Loyola University Stritch School of Medicine, (September 26-28, 1999).

Consultant, The Louisiana Board of Regents for Higher Education, Departmental Excellence Through Faculty Excellence (DEFE) Program, (March 2000)

SYMPOSIA AND COLLOQUIA - Invited Speaker and/or Organizer:

Invited Lecturer - 5th Gordon Conference on Cyclic AMP (1974)

Invited Speaker - Conference on Cyclic Nucleotides in Disease (1974) Sponsored by Physiological Society of Pennsylvania

Featured Speaker - Gulf Coast Tissue Culture Association (November, 1976)

Invited Speaker - 3rd International Conference on Cyclic Nucleotides, New Orleans, Louisiana (1977)

Symposium Speaker - Symposium on Cyclic Nucleotides and Neuropharmacology, Fall ASPET Meeting, Columbus, Ohio (1977)

Co-organizer - Symposium on Tachyphylaxis to Catecholamines, Fall Meeting of ASPET and SOT, Houston, Texas (1978)

Invited Faculty - EMBO Workshop on Receptors, Cyclic Nucleotides and Calcium, Glasgow, Scotland, August (1978)

Invited Faculty - NATO Course, Intracellular Communication of Signals in Normal and Cancer Cells, Brussels, Belgium (1980)

Chairman of Round Table Discussion on Cyclic Nucleotide Phosphodiesterases, 4th International Conference on Cyclic Nucleotides, Brussels, Belgium (1980)

Organizer - Symposium on Recent Developments in Molecular Pharmacology, Sponsored by Southwest Science Forum New York Academy of Science (affiliate), Houston (1981)

Speaker - Selected Topics in Pharmacology, Annual Meeting of Texas Pharmacologists (May, 1982)

Co-Organizer - First International Symposium on Cyclic Nucleotide
Phosphodiesterases, Houston, Texas (April, 1982)

Invited Participant - Round Table Discussion of Cyclic Nucleotide Phosphodiesterases, 6th International Conference on Cyclic Nucleotides and Protein Phosphorylation, Bethesda, Maryland (September, 1986)

Plenary Lecturer - Symposium on Tissue Specific Cyclic Nucleotide Phosphodiesterases and Their Inhibitors, Medicinal Chemistry Division, American Chemical Society 94th Annual Meeting, Denver, Colorado (April, 1987)

Invited Speaker - Sixth International Symposium on Calcium-Binding Proteins in Health and Disease, Nagoya, Japan (July, 1988).

Co-Organizer-2nd International Conference on Cyclic Nucleotide Phosphodiesterases, Tokushima, Japan (October, 1989)

Invited Speaker, Symposium in honor of Dr. Allan D. Bass's 80th Birthday, Vanderbilt University School of Medicine (February, 1990).

International Scientific Advisory Board - International Conference on Second Messengers and Phosphoproteins (1989-1992)

Organizing Committee, ASPET Colloquium on Multiple Phosphodiesterases, Newport Beach, California (April, 1994)

Chair: Symposium 2 - Multiple Phosphodiesterases: Pathophysiology, ASPET Colloquium on Multiple Phosphodiesterases (April, 1994)

Chair: Poster Session and Discussion, ASPET Colloquium on Multiple Phosphodiesterases (April, 1994)

Discussion Leader: Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases (June, 1998, Colby-Sawyer’s College, New Hampshire)

Invited Speaker, Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases, Watteville Valley, New Hampshire (June, 1999)

CURRENT GRANT SUPPORT

“Cardiovascular Research for Medical Students,” Southeast Affiliate, American Heart Association, Principal Investigator, 7/01/01-6/30/03, $21,600.

PAST GRANT SUPPORT (Direct Cost Only)

1. "Role of Cyclic Nucleotides in the Peripheral and Central Actions of Narcotics," Research Starter Grant, Pharmaceutical Manufacturers Association Foundation, 1/1/74 - 12/3/74; $5,000.

2. "Role of Cyclic Nucleotides in Adrenergic and Cholinergic Systems," Eli Lilly and Co., 3/1/73; $2,500.

3. "Role of Cyclic Nucleotides in the Peripheral and Central Actions of Narcotics," Merck Institute for Therapeutic Research, 3/15/74; $1,500.

4. "Role of Cyclic Nucleotide Phosphodiesterases in Cell Growth and Development," Mead Johnson Research Center, 1/16/74; $1,250.

5. "Faculty Development Award in Pharmacology," Recipient of 2 yr salary support, $20,000/yr; Pharmaceutical Manufacturers Association Foundation; 7/1/74 - 6/30/76.

6. "Postdoctoral Research Fellowship to Dr. W.J. Pledger, Sponsor, National Cancer Institute, 2 yr salary support plus $3,000/yr supply allowance; 6/74 - 5/76.

7. "Biological Role of Cyclic Nucleotide Phosphodiesterases," Co-Principal Investigator with Dr. W.J. Thompson, National Institiute of Health, GM- 21361; $111,012/3 yr; 1974-1977.

8. "The Isolation, Characterization and Biological Function of Cyclic 3'-5'-Nucleotide Phosphodiesterase Isozymes and Ornithine Decarboxylase in the Rat Testis," Principal Investigator, Project No. 6; Reproductive Biology Center Grant HD-08338; $69,291/3 yr; 1974-1977.

9. "Mechanisms of Narcotic Addiction," Co-Investigator with Dr. G.C. Rosenfeld, DA-00926, $113,822/3 yr; 6/1/74-5/31/77.

10. "Regulation of Cardiac Adenylyl Cyclase by Catecholamines, Co-Investigator with Dr.
W.J.Thompson, American Heart Institute (Texas Affiliate); NIH $7,500/1 yr; 1976-1977.

11. "Biological Role of Cyclic Nucleotide Phosphodiesterases," Co-Principal Investigator with Dr. W.J. Thompson, Competitive Renewals, NIH GM- 21361; $190,000/3 yr; 1977-1980; $384,000/4 yr; 1980-84; $372,000/3 yr; 1985-88.

12. "Hormonal Control of Cyclic Nucleotide Synthesis and Degradation in Rat Testis," Principal Investigator, Competitive Renewal, HD-08338 Project No.6; Male Reproduction Center Grant; $66,715/3 yr; 6/1/78-5/31/81.

13. "Cellular Interactions of Catecholamines and Insulin," Principal Investigator; Equipment Fund, $2,000; Texas Diabetes Research Foundation, 1978.

14. "Receptor Interactions of Insulin and Catecholamines," Principal Investigator: $25,000/yr; Redfern Foundation (Private Grant); 1978-79.

15. "Regulation of Phosphodiesterase by Covalent Modification," Senior International Fellowship, John E. Fogarty International Center for Advanced Study in the Health Sciences, University of Dundee, Department of Biochemistry, Dundee, Scotland, September 1, 1979 - August 31, 1980. Salary Support for Faculty Development Leave.

16. "Mechanism of Insulin Effects on Cyclic Nucleotide Metabolism," Principal Investigator, $23,300; Redfern Foundation, 1980.

17. "Hormonal Regulation of Isolated Gastric Mucosal Cell," Co-Investigator with Dr. G.C. Rosenfeld, NIH-AM 2043l, $163,101/3 yr; 4/1/78-3/31/81.

18. "Hormones and the Actions of Antidepressant Drugs," Co-investigator with Dr. S.J. Enna (University ofTexas Health Science Center), Subcontract MH 36945, $51,587; 9/1/83 - 8/31/85.

19. "Cyclic Nucleotide Studies," Principal Investigator, Ciba-Geigy Corporation, Pharmaceutical Division, $50,500; 1/1/85 - 12/31/86.

20. "Cyclic Nucleotide Studies in Heart and Lung," Principal Investigator, NOVA Pharmaceutical Corp., $9,680; 10/15/87-5/31/88.

21. "Biological Role of Cyclic Nucleotide Phosphodiesterase," Co-Principal Investigator with Dr. W. Joseph Thompson, NIH-GM 33538; Competitive Renewal; 9/27/85 - 2/28/89; $371,674.

22. "Regulation of Neurotransmitter Responses in the Central Nervous System", Co-Principal Investigator with Dr. S.J. Enna, Subcontract portion, Air Force Contract F49620-85-K-0014, Total Subcontract, 5/15/86 - 5/14/89; $120,668.

23. "Cocaine in the Developing Heart," Principal Investigator, Fraternal Order of Eagles, Max Baer Heart Fund, $5,000; July, 1989.

24 "Cyclic Nucleotide Phosphodiesterase Inhibitors", Principal Investigator, Roberts Pharmaceutical Corporation, $10,000; 1989.

25. "Mechanisms of Tissue Injury During Reperfusion Following Hemorrhagic Shock," Co-Investigator with Dr. Michael Artman, Office of Naval Research Grant; 7/01/88 - 12/31/90; $262,906 Total Award Direct Costs.

26. "Characterization of Myocardial Cyclic Nucleotide Phosphodiesterase Activities During Perinatal Maturation", American Heart Association - Alabama Affiliate, Co-Investigator with Michael Artman, M.D.; $25,000 direct costs, 7/1/90 - 6/30/91.

27. "The Role of Cyclic Nucleotides in Pulmonary Vascular Reactivity", American Heart Association - Alabama Affiliate, Co-Investigator with Johnson Haynes, M.D.; $50,000direct costs, 7/1/90 - 6/30/92.

28. "Effects of Hemorrhagic Shock and Retransfusion on the Myocardial Beta-adrenergic Transduction System," American Heart Association - Alabama Affiliate, Co-Investigator with David C. Mayer, M.D.; $50,000 direct costs, 7/01/91-6/30/93.

29. “Short-Term Research Training for Health Professionals,” Principal Investigator, NIH, 2T35 HL07509-16; 5/01/93-4/30/96; $34,524 direct cost.

30. "Mechanisms of Regulation of Rat Pulmonary Microvascular Endothelial Cell Permeability by Cyclic GMP," Sponsor, Advanced Predoctoral Fellowhsip for A. Hafeez Diwan, Pharmaceutical Research and Manufacturers of American Foundation, Inc.; 01/01/95-12/31/96; $25,000 total award.

31. "Endothelial Cell cGMP Receptors and Function," Co-Investigator (10% effort) with Dr. W.J. Thompson, NIH, 1R01 HL46494; 2/01/92-1/31/97; $864,940 total direct costs.

32. “Endothelial Cell cGMP Receptors and Function,” Co-Investigator (10% effort) with Dr. W.J. Thompson, NIH 2RO1 HL46494; 4/01/97-3/31/01; $1,063,959 total direct costs.

PUBLICATIONS

*Original Articles in Refereed Journals
**Chapters in Books and Monographs
***Editor of Books and Monographs

1. Green, V.A., Glenn, T.M., Strada, S.J. and Medina, G.: Cholinesterase Activity and Sulfonamide Absorption in Rats. J. Pharm. Sci. 55:516-517, 1966. (*)

2. Sulser, F., Owens, M.L., Strada, S.J. and Dingell, J.V.: Modification by Desipramine of the Norepinephrine Relaease by Reserpine in the Hypothalamus of the Rat In Vivo. J. Pharmacol. Exp. Ther. 168:272-282, 1969. (*)

3. Strada, S.J., Sanders-Bush, E. and Sulser, F.: Temporal Relationship Between Psychomotor Stimulation and Metabolism of Brain Norepinephrine. Biochem. Pharmacol. 19:262-269, 1970. (*)

4. Strada, S.J. and Sulser, F.: Comparative Effects of p-Chloramphetamine and Amphetamine on Metabolism and In Vivo Release of 3H-Norepinephrine in the Hypothalamus. Eur. J. Pharmacol. 15:45-51, 1971. (*)

5. Strada, S.J. and Sulser, F.: Effects of Monoamine Oxidase Inhibitors on Metabolism and In Vivo Release of 3H-Norepinephrine from the Hypothalamus. Eur. J. Pharmacol. 18:303-308, 1972. (*)

6. Strada, S.J., Klein, D.C., Weller, J. and Weiss, B.: Effect of Norepinephrine on the Concentration of Adenosine 3',5'-Monophosphate of Rat Pineal Gland in Organ Culture. Endocrinology. 90:1470-1475, 1972. (*)

7. Weiss, B., Lehne, R. and Strada, S.J.: A Rapid Microassay of Cyclic 3',5'-Adenosine Monophosphate Phosphodiesterase. Anal. Biochem. 45:222-235, 1972. (*)

8. Weiss, B. and Strada, S.J.: Neuroendocrine Control of the Adenosine 3',5'-Monophosphate System of Brain and Pineal Grand. Adv. Cyclic Nucleotide Res. 1:357-374, 1972. (**)

9. Costa, E., LeFevre, H., Meek, J., Revuelta, A., Spano, F., Strada, S. and Daly, J.: Serotonin and Catecholamine Concentrations in Brain of Rats Injected Intracerebrally with 5,6-dihydroxytryptamine. Brain Research 44:304-308, 1972. (*)

10. Strada, S.J.: Summary of Symposium on Central Adrenergic Mechanisms, BIS Conference Report, UCLA Brain Information Service No. 18:25-32, 1972. (**)

11. Weiss, B. and Strada, S.J.: Adenosine 3',5'-Monophosphate During Fetal and Postnatal Development. In: "Fetal Pharmacology", pp. 205-235. (Ed., L.A. Boreus) Raven Press, N.Y., 1973. (**)

12. Strada, S.J. and Weiss, B.: Increased Response to Catecholamines of the Cyclic AMP system of Rat Pineal Gland Induced by Decreased Sympathetic Activity. Arch. Biochem. Biophys. 160:197-204, 1974. (*)

13. Strada, S.J. and Robison, G.A.: Cyclic AMP as a Mediator of Hormonal Effects. In: MTP International Review of Science, "Endocrine Physiology", Physiology Series One, Volume 5, pp. 309-336, S.M. McCann (Ed.) Butterworth and Co., Ltd., London, England, and University Park Press, Baltimore, MD, USA, 1974. (**)

14. Strada, S.J. and Robison, G.A.: Recent Progress in Cyclic Nucleotide Research. Curr. Topics in Exper. Endocrinology 2:1-37, 1974. (**)

15. Strada, S.J., Uzunov, P. and Weiss, B.: Ontogenetic Development of a Phosphodiesterase Activator and the Multiple Forms of Cyclic AMP Phosphodiesterase of Rat Brain. J. Neurochem. 23:1097-1103, 1974. (*)

16. Pledger, W.J., Stancel, G.M., Thompson, W.J. and Strada, S.J.: Separation of Multiple Forms of Cyclic Nucleotide Phosphodiesterase from Rat Brain by Isoelectrofocusing. Biochim. Biophys. Acta 370:242-248, 1974. (*)

17. Strada, S.J. and Pledger, W.J.: Regulation and Characterization of Cyclic Nucleotide Phosphodiesterases in Mammalian Cells. In:"Cyclic Nucleotides in Disease", B. Weiss (Ed.) University Park Press, Baltimore, 1974, pp. 3-34. (**)

18. Dafny, N., McClung, R. and Strada, S.J.: Neurophysiological Properties of the Pineal Body I. Field Potentials. Life Sci. 16:611-620, 1975. (*)

19. Pledger, W.J., Thompson, W.J. and Strada, S.J.: Effects of Growth Conditions on Cyclic Nucleotide Phosphodiesterases of Cultured Fibroblasts. J. Cyclic Nucleotide Res. 1:251-259, 1975. (*)

20. Stancel, G.M., Thompson, W.J. and Strada, S.J.: Cyclic Nucleotide Phosphodiesterases in Uterine Development. Mol. Cell. Endocrinol. 3:283-295, 1975. (*)

21. Pledger, W.J., Thompson, W.J. and Strada, S.J.: Isolation of an Activator of Multiple Forms of Cyclic Nucleotide Phosphodiesterase of Rat Cerebrum by Isoelectric Focusing. Biochim. Biophys. Acta 391:334-340, 1975. (*)

22. Van Inwegen, R.G., Strada, S.J. and Robison, G.A.: Effects of Prostaglandins and Morphine on Brain Adenylyl Cyclase. Life Sci. 16:1875-1976. (*)

23. Strada, S.J., Kirkegaard, L. and Thompson, W.J.: Studies on Rat Pineal Gland Guanylate Cyclase. Neuropharmacology 15:261-266, 1975. (*)

24. Pledger, W.J., Thompson, W.J. and Strada, S.J.: Modification of Serum-Induced Changes in Cyclic Nucleotide Levels in Cultured Fibroblasts by Cyclic Nucleotide Phosphodiesterase. Nature 256:729-731, 1975. (*)

25. Van Inwegen, R.G., Pledger, W.J., Strada, S.J. and Thompson, W.J.: Characterization of Cyclic Nucleotide Phosphodiesterases with Multiple Separation Techniques. Arch. Biochem. Biophys. 175:700-709, 1976. (*)

26. Thompson, W.J., Ross, C.P., Pledger, W.J., Strada, S.J., Banner, R.L. and Hersh, E.M.: Cyclic AMP Phosphodiesterase: Distinct Forms in Human Lymphocytes and Monocytes. J. Biol. Chem. 251:4922-4929, 1976. (*)

27. Pledger, W.J., Thompson, W.J. and Strada, S.J.: Serum Modification of Cyclic Nucleotide Phosphodiesterase Forms Independent of Protein Synthesis. Biochem. Biophys. Res. Commun. 70:58-65, 1976. (*)

28. Van Inwegen, R.G., Swafford, R.L., Strada, S.J. and Thompson, W.J.: Characterization of Particulate Cyclic Nucleotide Phosphodiesterases of Rat Kidney. Arch. Biochem. Biophys. 178:58-68, 1977. (*)

29. Thompson, W.J. and Strada, S.J.: Hormonal Regulation of Cyclic Nucleotide Phosphodiesterases. In: "Receptors and Hormone Action", Vol. III. L. Birnbaumer and B. O'Malley (Eds.), Academic Press, New York, pp. 553-577, 1978. (**)

30. Strada, S.J. and Thompson, W.J.: Multiple Forms of Cyclic Nucleotide Phsophodiesterase: Anomalies or Biologic Regulators? Adv. Cyclic Nucleotide Res. 9:265-283, 1978. (**)

3l. Hickie, R., Couture-Muriello, E., Strada, S.J., Thompson, W.J., Morris, H.P. and Robison, G.A.: Comparison of Cyclic Adenosine 3',5'-Monophosphate and Cyclic Guanosine 3',5'-Monophosphate Levels, Cyclases and Phosphodiesterases in Morris Hepatomas and Liver. Cancer Res. 37:3599-3606, 1977. (*)

32. Epstein, P.M., Mills, J.S., Ross, C.P., Strada, S.J., Hersh, E.M. and Thompson, W.J.: Proliferation and Malignancy in Human and Murine Lymphoid Cells: Association with Increased Cyclic Nucleotide Phosphodiesterase Activity. Cancer Res. 37:4016-4023, 1977. (*)

33. Achar, S.B., Strada, S.J., Sanders, R.B., Pledger, W.J., Thompson, W.J., and Robison, G.A.: Sonication as a Tool for the Study of Adenylyl Cyclase Activity. J. Cyclic Nucl. Res. 3:189-198, 1977. (*)

34. Heindel, J.J., Hintz, M.I., Steinberger, E. and Strada, S.J.: Effects of FSH on Cyclic Nucleotide Accumulation in Testes of Rats of Various Ages. Endocrine Res. Comm. 4:311-328, 1977. (*)

35. Epstein, P.M., Pledger, W.J., Gardner, E.A., Stancel, G.M., Thompson, W.J. and Strada, S.J.: Activation of Mammalian Cyclic AMP Phosphodiesterases by Trypsin. Biochim. Biophys. Acta. 527:442-455, 1978. (*)

36. Pledger, W.J., Gardner, R.M., Epstein, P.M., Thompson, W.J. and Strada, S.J.: Cell Cycle Traverse and Macromolecular Synthesis in BHK Fibroblasts as Affected by Insulin. Exp. Cell Res. 118:389-394, 1979. (*)

37. Thompson, W.J., Terasaki, W.L., Epstein, P.M. and Strada, S.J.: Assay of Cyclic Nucleotide Phosphodiesterase and Resolution of Multiple Molecular Forms of the Enzyme. Adv. Cyclic Nucl. Res. 10:69-92, 1979. (**)

38. Heindel, J.J., Williams, E., Robison, G.A. and Strada, S.J.: Inhibition of GH1 Rat Pituitary Tumor Cell Adenylyl Cyclase Activity by Somatostatin. J. Cyclic Nucl. Res. 4:453-462, 1978. (*)

39. Morishima, I., Thompson, W.J., Robison, G.A. and Strada, S.J.: Loss and Restoration of Sensitivity to Epinephrine in Cultured BHK cells: Effect of Inhibitors of RNA and Protein Synthesis. Mol. Pharmacol. 18:370-378, 1980. (*)

40. Gardner, E.A., Thompson, W.J., Strada, S.J. and Stancel, G.M.: Catalytic Structural and Regulatory Properties of Soluble Uterine Phosphodiesterases. Biochemistry: 17:2995-3000, 1978. (*)

41. Pledger, W.J., Thompson, W.J. and Strada, S.J.: Regulation of Cyclic Nucleotide Phosphodiesterase Forms by Serum and Insulin in Cultured Fibroblasts. J. Cellular Physiol. 100:497-508, 1979. (*)

42. Epstein, P.M., Mills, J.S., Hersh, E.M., Strada, S.J. and Thompson, W.J.: Activation of Cyclic Nucleotide Phosphodiesterase from Isolated Human Peripheral Blood Lymphocytes by Mitogenic Agents. Cancer Res. 40:379-386, 1980. (*)

43. Strada, S.J. and Martin, M.W.: Neuropharmacological Control of Pineal Gland Cyclic Nucleotide Systems. In: "Neuropharmacology of Cyclic Nucleotides", G.C. Palmer (Ed.), Urban and Schwarzenberg, Baltimore, MD, pp. 173-196, 1979. (**)

44. Strada, S.J.: Pharmacological Aspects of Antiparkinsonian Drugs. In: Aging, Vol. 9, "Neuropsychiatric Side Effects of Drugs in the Elderly" A.M. Levenson, Ed., Chapter 8, Raven Press, New York, pp. 89-104, 1979. (**)

45. Robison, G.A., Strada, S.J., Thompson, W.J., Morishima, I. and Couture-Murillo, B.: Tachyphylaxis to Catecholamines in Cultured BHK Cells. In: "Catecholamines: Basic and Clinical Frontiers," Vol. 1, E. Usdin, I.J. Kopin and J. Barchas, Eds., Pergamon Press, Elmsford, New York, pp. 480-482, 1979. (**)

46. Thompson, W.J., Epstein, P.M. and Strada, S.J.: Purification and Characterization of High Affinity Cyclic AMP Phosphodiesterase from Dog Kidney. Biochemistry, 18:5228-5237, 1979. (*)

47. Thompson, W.J., Ross, C.P., Strada, S.J., Hersh, E.M. and Lavis, V.R.: Comparative Analyses of Cyclic Adenosine 3',5'-Monophosphate Phosphodiesterases of Human Peripheral Blood Monocytes and Cultured P 388D1 Cells. Cancer Res. 40:1955-1960, 1980. (*)

48. Thompson, W.J., Ross, C.P., Hersh, E.M., Epstein, P.M. and Strada, S.J.: Activation of Human Lymphocyte High Affinity Cyclic AMP Phosphodiesterase by Culture with 1-Methyl-3-Isobutylxanthine. J. Cyclic Nucl. Res. 6:25-36, 1980. (*)

49. Lavis, V.R., Thompson, W.J. and Strada, S.J.: Effects of Insulin on Glycogen Metabolism of Serum-Deprived BHK-21 Fibroblasts. J. Cellular Physiol. 103:55-62, 1980. (*)

50. Rosenfeld, G.C., Strada, S.J. and Robison, G.A.: Cyclic Nucleotides and the Central Effects of Opiates: an Overview of Current Research. In:"Neurochemical Mechanisms of Opiates and Endorphins", (Adv. Biochem. Psychopharmacol. Vol. 20, H.H. Loh and D.H. Ross, Eds.), Raven Press, New York, pp. 261-279, 1979. (**)

51. Rosenfeld, G.C., Strada, S.J., Dial, E..J., Bearer, C.F. and Thompson, W.J.: Histamine, Cyclic Nucleotides and Gastric Parietal Cell Secretion. Adv. CyclicNucl. Res. 12:255-266, 1980. (**)

52. Lavis, V.R., Strada, S.J., Ross, C.P., Hersh, E.M. and Thompson, W.J.: Comparison of the Responses of Freshly Isolated and Cultured Human Monocytes and P 388D1 Cells to Agents Affecting Cyclic AMP Metabolism. J. Lab. Clin.Med., 96:551-556, 1980. (*)

53. Heindel, J.J., Steinberger, A. and Strada, S.J.: Identification and Characterization of a Beta1 Adrenergic Receptor in the Rat Sertoli Cell. Mol. Cell. Endocrinol., 22:349-358, 1981. (*)

54. Strada, S.J., Epstein, P.M., Gardner, E.A., Thompson, W.J. and Stancel, G.M.: Evidence for Convertible Forms of Soluble Uterine Cyclic Nucleotide Phosphodiesterase. Biochim. Biophys. Acta. 661:12-20, 1981(*)

55. Strada, S.J.: Cyclic Nucleotide Phosphodiesterases. In: "Cell Regulation by Intracellular Signals", S. Swillens, J.E. Dumont, Eds., Plenum Publishing London, pp. 95-108, 1982. (**)

56. Ghetti, B., Truex, L., Sawyer, B., Strada, S.J. and Schmidt, M.J.: Exaggerated Cyclic AMP Accumulation and Glial Cell Reaction in the Cerebellum During Purkinje Cell Degeneration in pcd Mutant Mice. J. Neurosci. Res. 6:789-801, 1981. (*)

57. Sarada, K., Epstein, P.M., Strada, S.J. and Thompson, W.J.: Analysis of Cyclic Nucleotide Phosphodiesterase(s) by Radioimmunoassay. Arch. Biochem. Biophys. 215:183-198, 1982. (*)

58. Cohen. P., Foulkes, J.G., Goris, J., Hemmings, B., Ingebritsen, T.S., Stewart,A.A. and Strada, S.J.: Classification of Protein Phosphatases Involved in Cellular Regulation. In: "Metabolic Interconversion of Enzymes" 1980, H. Holzer, Ed., Springer-Verlag, Berlin, pp. 28-43, 1980. (**)

59. Epstein, P.M., Strada, S.J., Sarada, K. and Thompson, W.J.: Catalytic and Kinetic Properties of a High Affinity Form of Cyclic AMP Phosphodiesterase from Dog Kidney. Arch. Biochem. Biophys. 218:119-133, 1982. (*)

60. Heindel, J.J., Berkowitz, A., Steinberger, A. and Strada, S.J.: Modification of Sertoli Cell Responsiveness to FSH by Cryptorchidism and Hypophysectomy in Immature and Adult Rats. Amer. J. Androl. 3:337-343, 1982. (*)

61. Lavis, V.R., Davenport, R.A., Pontier, P., Thompson, W.J. and Strada, S.J.: Cyclic AMP Does Not Modulate Hexose Uptake of Serum-Deprived BHK-21 Fibroblasts. J. Cellular Physiol. 112:373-375, 1982. (*)

62. Enna, S.J. and Strada, S.J.: Postsynaptic Receptors: Recognition Sites, Ion Channels and Second Messengers. In: "The Clinical Neurosciensces": Neurology, Neurosurgery, Neuropathology, Neuroradiology and Neurobiology, R. Rosenberg, R. Grossman, S. Schochet, E.R. Heinz and W. Willis (Eds.), Churchill Livingstone, New York, pp. 145-170, 1983. (**)

63. Foulkes, J.G., Cohen, P., Strada, S.J., Everson, W.V. and Jefferson, C.S.: Antagonistic Effects of Insulin and β-Adrenergic Agonists on the Activity of Protein Phosphatase Inhibitor-1 in Skeletal Muscle of the Perfused Rat Hemicorpus. J. Biol. Chem. 257:12493-12496, 1982. (*)

64. Foulkes, J.G., Strada, S.J., Henderson, P.J.F. and Cohen, P.: A Kinetic Analysis of the Effects of Inhibitor-1 and Inhibitor-2 on the Activity of Protein Phosphatase-1. Eur. J. Biochem., 132:309-313, 1983. (*)

65. Souness, J.E., Thompson, W.J., Strada, S.J. and Stouffer, J.E.: The Effect of N6-phenylisopropyladenosine on the Regulation of Fat Cell Hexose Transport, Glucose Oxidation and Fatty Acid Release by Insulin and Catecholamines. FEBS Lett. 153:103-107, 1983. (*)

66. Strada, S.J., Martin, M.W. and Thompson, W.J.: General Properties of Multiple Molecular Forms of Cyclic Nucleotide Phosphodiesterase in the Nervous System. Adv. Cyclic Nucl. and Prot. Phos. Res. 16:13-29, 1984. (**)

67. Thompson, W.J., Pratt, M.L. and Strada, S.J.: Biochemical Properties of High Affinity Cyclic AMP Phosphodiesterase(s). Adv. Cyclic Nucl. and Prot. Phos. Res. 16:137-148, 1984. (**)

68. Robison, G.A., Kishi, Y., Kahl, A., Skolnick, M.H., Smigel, M.D., Strada, S.J. and Thompson, W.J.: A New Method for the Analysis of Cyclic AMP Phosphodiesterase Activity: Evidence for Two Interconvertible Forms. Adv. Cyclic Nucl. Prot. Phos. Res. 16:337-356, 1984 (**)

69. Strada, S.J. and Thompson, W.J. (editors): "Cyclic Nucleotide Phosphodiesterases", Vol. 16, Advances in Cyclic Nucleotide and Protein Phosphorylation Research, 1984, 442 pp. (***)

70. Thompson, W.J. and Strada, S.J.: 1.9 Cyclic Nucleotide Phosphodiesterase (PDE) 3':5"-Cyclic Nucleotide 5'-Nucleotidohydrolyase, EC 3.1.4.17. In Methods of Enzymatic Analysis, 3rd Edition, H.U. Bermeyer, J. Bergmeyer and M. Grassl, (Eds.), GmbH, D-6940 Weinheim, pp. 127-134, 1984. (**)

71. Onali, P.L., Strada, S.J., Epstein, P.M. and Thompson, W.J.: Purification and Characterization of High Affinity Cyclic Nucleotide Phosphodiesterase from Human Myelogenous Leukemia Cells. Cancer Res., 45:1384-1391, 1985. (*)

72. Shenolikar, S., Thompson, W.J. and Strada, S.J.: Characterization of a Calcium-Calmodulin Stimulated Cyclic GMP Phosphodiesterase from Bovine Brain. Biochemistry 24:672-678, 1985. (*)

73. Souness, J.E., Thompson, W.J. and Strada, S.J.: Adipocyte Cyclic Nucleotide Phosphodiesterase Activation by Vanadate. J. Cyclic Nucl. Prot. Phos. Res. 10:383-396, 1985. (*)

74. Duman, R.S., Strada, S.J. and Enna, S.J.: The Effect of Imipramine and Adrenocorticotropin Administration on Rat Brain Norepinephrine-Coupled Cyclic Nucleotide Generating System: Alterations in α- and β-Adrenergic Components. J. Pharmacol. Exp. Ther. 234:409-414, 1985. (*)

75. Hanley, R.M., Strada, S.J., Steiner, A.L., Thompson, W.J. and Shenolikar, S.: Increase in Liver Protein Phosphatase-1 in Spontaneously Diabetic Chinese Hamsters. Mol. Cell. Endo. 50:115-122, 1987. (*)

76. Thompson, W.J., Shen, C-C., and Strada, S.J.: Purification of High Affinity Cyclic AMP Phosphodiesterase from Dog Kidney. Meth. Enzymol. 159:760- 766, 1988. (**)

77. Black, E.W., Strada, S.J. and Thompson, W.J.: Relationships of Secretogogue Induced cAMP Accumulation and Acid Secretion in Elutriated Rat Gastric Parietal Cells. J. Pharm. Met. 20(1):57-78, 1988. (*)

78. Kithas, P.A., Artman, M.F., Thompson, W.J. and Strada, S.J.: Subcellular Distribution of High Affinity Type IV Cyclic AMP Phosphodiesterases in Rabbit Myocardium: Relationship to the Effects of Cardiotonic Drugs. Circ. Res. 62:782-789, 1988. (*)

79. Whalin, M.E., Strada, S.J. and Thompson, W.J.: Purification and Partial Characterization of Membrane-Associated Type II (cGMP-Activatable) Cyclic Nucleotide Phosphodiesterase From Rabbit Brain. Biochim. Biophys. Acta 972:79-94, 1988. (*)

80. Artman, M., Kithas, P.A., Wike, J.S. and Strada, S.J.: Inotropic Responses Change During Postnatal Maturation in the Rabbit. Am. J. Physiol. 255 (Heart Circ. Physiol. 24):H335-H342, 1988. (*)

81. Artman, M., Kithas, P.A., Wike, J.S., Crump, D.B. and Strada, S.J.: Inotropic Responses to Cyclic Nucleotide Phosphodiesterase Inhibitors in Immature Rabbit Myocardium. J. Cardiovas. Pharmacol. 13:146-154, 1989. (*)

82. Black, E.W., Strada, S.J., Garrett, R.L., Kvietys, P.R., Thompson, W.J. and Norman, J.A.: Inhibition of Gastric Acid Secretion In Vivo and In Vitro by a New Calmodulin Antagonist, CGS 9343B. J. Pharmacol. Exp. Ther. 248:208-214, 1989. (*)

83. Kithas, P.A., Artman, M., Thompson, W.J. and Strada, S.J.: Subcellular Distribution of High-Affinity Type IV Cyclic AMP Phosphodiesterase Activities in Rabbit Ventricular Myocardium: Relation to Postnatal Maturation. J. Molec. Cell. Cardiol. 21:507-517,1989. (*)

84. Black, E.W., Cornwell, T.L., Lincoln, T.M., Strada, S.J. and Thompson, W.J.: Fura-2 Analysis of Cytosolic Calcium Regulation in Rat Gastric Parietal Cells. J. Cell. Physiol. 139:250-259, 1989. (*)

85. Duman, R.S., Strada, S.J. and Enna, S.J.: Glucocorticoid Administration Increases Receptor-Mediated and Forskolin-Stimulated Cyclic AMP Accumulation in Rat Brain Cerebral Cortical Slices. Brain Res. 477:166-171, 1989. (*)

86. Strada, S.J., Kithas, P.A., Whalin, M.E. and Thompson, W.J.: Molecular Properties of Cyclic Nucleotide Phosphodiesterase Isozymes. In: "Calcium Protein Signaling," H. Hidaka, Ed., Plenum Press, New York, Adv. Exp. Med. Biol. 255:409-423, 1989. (**)

87. Strada, S.J., Duman, R.S. and Enna, S.J.: Analysis of Neurotransmitter Receptor-Coupled Cyclic Nucleotide Systems: Cyclic AMP and Adenylate Cyclase. In: "Methods in Neurotransmitter Receptor Analysis," H. Yamamura, M. Kuhar and S.J. Enna (Eds.), Raven Press, New York, pp. 89-110, 1989. (**)

88. Whalin, M.E., Garrett, R.L., Jr., Thompson, W.J. and Strada, S.J.: Correlation of Cell-Free Brain Cyclic Nucleotide Phosphodiesterase Activities to Cyclic AMP Decay in Intact Brain Slices. Sec. Mess. Phosphoprot. 12(5&6):311-325, 1988-89.(*)

89. Whalin, M.E., Scammell, J.G., Thompson, W.J. and Strada, S.J.:Regulation of cAMP Metabolism in PC12 Cells by Type II (cGMP-Activatable) Cyclic Nucleotide Phosphodiesterase. In: "Purine Nucleosides and Nucleotides In Cell Signalling: Targets For New Drugs," K.A. Jacobson, J.W. Daly and V.C. Manganiello, (Eds.), Springler-Verlag, New York, Inc., pp. 323-328, 1990. (**)

90. Whalin, M.E, Scammell, J.G., Strada, S.J. and Thompson, W.J.: PDE II (the cGMP- Activatable Cyclic Nucleotide Phosphodiesterase) Regulates Cyclic AMP Metabolism in PC12 Cells. Mol. Pharm., 39:711-717, 1991. (*)

91. Haynes, Jr., J., Kithas, P.A., Taylor, A.E. and Strada, S.J.: Selective Inhibition of cGMP-Inhibitable cAMP Phosphodiesterase Decreases Pulmonary Vasoreactivity. Amer. J. Physiol., 261 (Heart Circ. Physiol. 30): H487-492, 1991. (*)

92. Thompson, W.J., Tan, Boen H. and Strada, S.J.: Activation of Rabbit Liver High Affinity cAMP (Type IV) Phosphodiesterase by a Vandyl/Gluthathione Complex: Characterization of the Role of the Sulfhydryl. J. Biol. Chem., 266: 17011-17019, 1991. (*)

93. Thompson, W.J., Lavis, V.R., Whalin, M.E. and Strada, S.J.: Regulatory Mechanisms of Particulate Cyclic Nucleotide Phosphodiesterases. Adv. Sec. Mess. Phosphoprot. Res. 25: 165-183, 1992. (**)

94. Strada, S.J. and Hidaka, H. (editors). "The Biology of Cyclic Nucleotide Phosphodiesterases", Vol. 25, Advances in Second Messenger and Phosphoprotein Research, 416pp. 1992. (***)

95. Mayer, D.C., Strada, S.J., Hanson, A. and Artman, M.: Effects of Hemorrhagic Shock and Retransfusion on Catalase and Superoxide Dismutase Activities In Rabbits. Circ. Shock, 36:147-153, 1992.(*)

96. Artman, M., Oquist, N.L. and Strada, S.J.: Myocardial Inotropic Responses to Selective and Non-selective Phosphodiesterase Inhibitors in Newborn, Immature, and Adult Rabbits. Pediatric Res., 31:300-304, 1992.(*)

97. Haynes, J., Robinson, J., Saunders, L., Taylor, A.E. and Strada, S.J.: The Role of cAMP-dependent Protein Kinase in cAMP Mediated Vasodilation. Amer. J. Physiol., 262 (Heart Circ. Physiol. 31): H511-H516, 1992.(*)

98. Mehta, C.S. and Strada, S.J.: Effects of Acute and Continuous Administration of Morphine on the Cyclic AMP Response Induced by Norepinephrine in Rat Brain Slices. Life Sci., 55:34-42, 1994.(*)

99. Barnard, J.W., Seibert, A.F., Prasad, V.R., Smart, D.A., Strada, S.J., Taylor, A.E. and Thompson, W.J.: Reversal of Pulmonary Capillary Ischemia-Reperfusion Injury by Rolipram, a Cyclic AMP Phosphodiesterase Inhibitor. J. Appl. Physiol., 77(2):1-8, 1994.(*)

100. Diwan, A.H., Thompson, W.J., Lee, A.K. and Strada, S.J.: Cyclic GMP-dependent Protein Kinase Activity in Rat Pulmonary Microvascular Endothelial Cells. Biochem. Biophys. Res. Comm., 202:728-735, 1994.(*)

101. Mayer, D.C., Strada, S.J., Hoff, C., Hunter, R. and Artman, M.: Effects of Poloxamer 188 in a Rabbit Model of Hemorrhagic Shock. Annals Clin. Lab. Sci., 24(4):302-311, 1994.(*)

102. Thompson, M.E., Valentine, D.L., Strada, S.J., Wagner, J.A. and Scammell, J.G.: Transcriptional Regulation of Secretogranin II and Chromogranin B by Cyclic AMP in a Rat Pheochromocytoma Cell Line. Mol. Pharm., 46: 880-889, 1994.(*)

103. Polson, J.B. and Strada, S.J.: Cyclic Nucleotide Phosphodiesterases and Smooth Muscle. Ann. Rev. Pharmacol. Toxicol. 36:403-427, 1996. (**)

104. Ashikaga, T., Robertson, D.W., Sportsman, R.J., Strada, S.J. and Thompson, W.J.: Comparison of Indolidan Binding Sites of Drug Antibodies and Sarcoplasmic Reticulum with Inhibition of Cyclic AMP Phosphodiesterase. J. Receptor and Signal Transduction Res., 16:315-337, 1996. (*)

105. Reynolds, P., Strada, S.J. and Thompson, W.J.: Application of a New Prelabeling Technique to Measure Cyclic GMP Accumulation in Intact Pulmonary Microvascular Endothelial Cells. Life Sci., 60:909-918, 1997. (*)

106. Diwan, A.H., Honkanen, R.E., Schaeffer, R.C., Jr., Strada, S.J. and Thompson, W.J.: Inhibition of Serine-Threonine Protein Phosphatases Decreases Barrier Function of Rat Pulmonary Microvascular Endothelial Cells. J. Cell. Physiol., 171:259-270, 1997. (*)

107. Ashikaga, T., Strada, S.J. and Thompson, W.J.: Altered Expression of Cyclic Nucleotide Phosphodiesterase Isozymes During Culture of Aortic Endothelial Cells. Biochem. Pharm., 54:1071-1079, 1997. (*)

108. Henderson, J.D., and Strada, S.J. Potential Drug Interactions with Herbal Medicinal Products. Advances for Physician Assistants, 10:33-43, 2002(*)

109. Thompson, W.J., Ashkikaga, T., Kelly, J.J., Liu, L., Zhu, B., Vemavarapu, L. and Strada, S.J. Regulation of Cyclic AMP in Rat Pulmonary Microvascular Endothelial Cells by Rolipram-Sensititve Cyclic AMP Phosphodiesterase (PDE4). Biochem. Pharmacol., 63:797-807, 2002. (*)

ABSTRACTS

1. Glenn, T.M., Green, V.A., Medina, G. and Strada, S.J.: The Interaction of Guanethidine and Neostigmine on Amine Levels in the Rat. Fed. Proc. 24:372, 1965.

2. Strada, S.J. and Sulser, F.: Modification of the Availability of Norepinephrine in the Hypothalamus of the Unanesthetized Rat. Fed. Proc. 28:2995, 1969.

3. Strada, S.J., Sanders-Bush, E. and Sulser, F.: Comparative Studies on the Mode of Action of Amphetamine and p-Chloramphetamine. Pharmacologist 11:159, 1969.

4. Strada, S.J. and Sulser, F.: In Vivo Release of Norepinephrine in the Hypothalamus: Modification by p-Chloramphetamine and Amphetamine. Fed. Proc. 29:417, 1970.

5. Weiss, B., Uzunov, P., Strada, S.J. and Lehne, R.: Postnatal Ontogenesis of Adenyl Cyclase, Phosphodiesterase, and Cyclic 3',5'-Adenosine Monophosphate in Rat Brain and Pineal Gland. Int. Cong. Physiol. Sci. 25:600, 1971.

6. Strada, S.J., Uzunov, P. and Weiss, B.: Increased Sensitivity to Norepinephrine (NE) of the Cyclic 3',5' AMP System of Rat Brain Following 6-Hydroxydopamine (6-HDM). Pharmacologist 13:367, 1971.

7. Strada, S.J. and Uzunov, P.: Distribution and Ontogenetic Development of Multiple Phosphodiesterase Activities of Rat Brain. Fed. Proc. 31:514, 1972.

8. Strada, S.J. and Weiss, B.: Increased Sensitivity of the Cyclic 3',5'-AMP System of Rat Pineal Gland Induced by Decreased Sympathetic Nerve Activity. Soc. for Neurosci. 2:229, 1972.

9. McClung, R., Dafny, N. and Strada, S.J.: Pineal Body and Hypothalamic Evoked Responses Following Acoustic and Amygdala Stimulation in Freely Behaving Rats. Soc. for Neurosci. 3:521, 1974.

10. Pledger, W.J., Stancel, G.M. and Strada, S.J.: Separation of Multiple Forms of Cyclic Nucleotide Phosphodiesterases from Rat Brain Using Isoelectrofocusing. Fed. Proc. 33:824-825, 1975.

11. Thompson, W.J., Pledger, W.J., Van Inwegen, R.G. and Strada, S.J.: Regulation of Mammalian Cyclic Nucleotide Phosphodiesterases. Adv. Cyclic Nucleotide Res. 5:824-825, 1975.

12. Strada, S.J., Kirkegaard, L. and Thompson, W.J.: Guanylate Cyclase and Cyclic GMP Phosphodiesterase of High Specific Activities in Rat Pineal Gland. Adv. Cyclic Nucleotide Res. 5:822-823, 1975.

13. Pledger, W.J., Palmer, G.C. and Strada, S.J.: Characterization of Cyclic Nucleotide Phosphodiesterases in Neuronal and Glial Enriched Fractions of Rat Brain. Soc. for Neurosci. 4:386, 1974.

14. Thompson, W.J., Stancel, G.M. and Strada, S.J.: Cyclic Nucleotide Phosphodiesterases in Uterine Development. Texas Rep. Biol. 33:335-336, 1975.

15. Pledger, W.J. and Strada, S.J.: Cyclic Nucleotide Phosphodiesterase (CN PDE) Mediation of Serum-Induced Changes in Growth and Cyclic Nucleotide (CN) Levels of Cultured Fibroblasts, Fed. Proc. 34:264, 1975.

16. Strada, S.J., Thompson, W.J. and Stancel, G.M.: Possible Participation of Cyclic Nucleotide Phosphodiesterases in the Response of Immature Rat Uterus to Estrogens. International Congress of Pharmacology 6:610, 1975.

17. Hintz, M.I., Strada, S.J. and Steinberger, E.: Cyclic Nucleotide Phosphodiesterases of Rat Testes. Society for the Study of Reproduction 8:121, 1975.

18. Strada, S.J., Martin, M.W. and Thompson, W.J.: Neuroendocrine Control of Pineal and Adrenal Guanylate Cyclases. Soc. for Neurosci. 5:459, 1975.

19. Van Inwegen, R.G., Martin, M.W., Robison, G.A. and Strada, S.J.: Characteristics of Brain Adenylate Cyclases: Novel Effects of Adrenergic Agonists and Antagonists. Soc. for Neurosci. 5:313, 1975.

20. Strada, S.J., Pledger, W.J. and Van Inwegen, R.G. and Thompson, W.J.: Cellular Regulation of Cyclic Nucleotide Phosphodiesterases. Proc. 2nd Int. Cong. Pathophysiol. 2:397, 1975.

21. Pledger, W.J., Thompson, W.J. and Strada, S.J.: Permissive Action of Insulin on the Growth of Cultured Fibroblasts: Relation to Effects on RNA, DNA, Protein Synthesis and Cyclic Nucleotide Metabolism. Fed. Proc. 35:366, 1976.

22. Achar, S.B., Strada, S.J., Sanders, R.B., Robison, G.A. and Thompson, W.J.: Hormonal Regulation of Adenylyl Cyclase of Cultured Fibroblasts: Application of A Sonication Technique. Fed. Proc. 35:423, 1976.

23. Morishima, I., Strada, S.J., Thompson, W.J. and Robison, G.A.: Desensitization of the Hormonal Responsiveness of the Adenylyl Cyclase - Cyclic AMP System of Cultured Fibroblasts. 58th Ann. Mtg. Endocrine Soc. Abst. No. 36, 1976.

24. Hintz, M.I., Steinberger, E. and Strada, S.J.: Characteristics of Cyclic Nucleotide Phosphodiesterases in Rat Testes During Development. 58th Ann. Mtg. Endocrine Soc. Abst. No. 605, 1976.

25. Hickie, R.A., Thompson, W.J., Strada, S.J., Robison, G.A. and Morris, H.P.:Comparison of Cyclic AMP and Cyclic GMP Synthesis and Hydrolysis in Rat Hepatomas. Fed. Proc. 36:1714, 1976.

26. Martin, M.W., Thompson, W.J. and Strada, S.J.: Catecholamine Desensitization in Rat Pineal Gland: Uncoupling of β-Adrenergic Receptors from Adenylyl Cyclase Activity. Pharmacologist 18:220, 1976.

27. Morishima, I., Thompson, W.J., Robison, G.A. and Strada, S.J.: Mechanism of Catecholamine Desensitization of Cultured Fibroblasts. Pharmacologist 18:186, 1976.

28. Thompson, W.J., Ross, C.P., Hersh, E.M., Strada, S.J. and Epstein, P.M.: Non-Genetic Regulation of a Specific Form of Lymphocyte Cyclic AMP Phosphodiesterase. Fed. Proc. 36:283, 1977.

29. Epstein, P.M., Pledger, W.J., Thompson, W.J. and Strada, S.J.: Modification of the Physical Properties of Cyclic Nucleotide Phosphodiesteraes. Fed. Proc. 36:283, 1977.

30. Gardner, E.A., Thompson, W.J., Stancel, G.M. and Strada, S.J.: Structural, Catalytic and Regulatory Properties of Uterine Cyclic Nucleotide Phosphodiesterases. Fed. Proc. 36:320, 1977.

31. Mills, J.S., Epstein, P.M., Strada, S.J. and Thompson, W.J.: Purification of 3',5'-Cyclic Nucleotide Phosphodiesterases from Dog Kidney. Adv. Cyclic Nucl. Res. 9:758, 1978.

32. Ross, C.P., Lavis, V.R., Strada, S.J. and Thompson, W.J.: Cyclic AMP Phosphodiesterase Activity of Circulating Human Monocytes. Adv. Cyclic Nucl. Res. 758, 1978.

33. Morishima, I., Strada, S.J., Thompson, W.J. and Robison, G.A.: Studies on the Loss and Restoration of Sensitivity of BHK Cells to Stimulation by Beta Adrenergic Agonists. Adv. Cyclic Nucl. Res. 9:780, 1978.

34. Thompson, W.J., Strada, S.J., Couture-Murillo, B. and Robison, G.A.:Differential Developmental of Rat Heart Adenylyl Cyclase and Receptor Binding. Pharmacologist 19:202, 1977.

35. Strada, S.J., Gardner, E.A., Thompson, W.J., Epstein, P.M. and Stancel, G.M.: Kinetic and Regulatory Characteristics of Uterine Phosphodiesterases. Pharmacologist 19:203, 1977.

36. Ross, C.P., Thompson, W.J., Lavis, V.R. and Strada, S.J.: Metabolism of Cyclic AMP by Human Monocytes. Amer. Fed. Clin. Res. 26(1) A34, 1978.

37. Epstein, P.M., Mills, J.S., Hersh, E.M., Strada, S.J. and Thompson, W.J.: ATP-Dependent Regulation of Low Km Cyclic AMP Phosphodiesterases by a Protein Isolated from Human Lymphocytes. Fed. Proc. 37:1302, 1978.

38. Metha, C.S., Rosenfeld, G.C. and Strada, S.J.: Altered Cyclic AMP Response to Norepinephrine Induced by Acute and Chronic Morphine Administration. Fed. Proc. 37:772, 1978.

39. Lavis, V., Strada, S.J., Pledger, W.J., Thompson, W.J. and Epstein, P.M.:Effects of Insulin on Regulation of Glycogen Metabolism and Cell Cycle in Cultured Fibroblasts. Endocrine Soc. Abst. No. 277, p. 213, 1978.

40. Robison, G.A., Strada, S.J., Thompson, W.J., Morishima, I. and Couture-Murillo, B.: Tachphylaxis to Catecholamines in Cultured BHK Cells, 7th Int. Cong. Pharmacol. Paris, France, 1978.

41. Rosenfeld, G.C., Gerba, P., Strada, S.J. and Thompson, W.J.: Stimulation by Acid Sercretagogues on14C-Aminopyrine Accumulation into Isolated Rat Gastric Mucosal Parietal Cells. Pharmacologist 20:209, 1978.

42. Ross, C.P., Martin, M.W., Thompson, W.J., Lavis, V.R. and Strada, S.J.: Cyclic AMP Metabolism by Monocytes and Macrophages. Amer. Fed. Clin. 26:426A, 1978.

43. Heindel, J.J., Steinberger, A. and Strada, S.J.: Identification of a Beta-adrenergic Receptor in the Rat Sertoli Cell. Endocrinol. Soc., 1979, Abst. No. 724, p. 353.

44. Martin, M.W., Thompson, W.J. and Strada, S.J.: Substrate Specificity and Calcium Sensitivity of Soluble Brain Phosphodiesterases Separated in the Presence and Absence of EGTA. Fed. Proc. 38:262, 1979.

45. Epstein, P.M., Gardner, E.A., Stancel, G.M., Strada, S.J. and Thompson, W.J.: Separation of Uterine Cyclic AMP and Cyclic GMP Phosphodiesterase Activity by Trypsin Treatment. Fed. Proc. 38:262, 1979.

46. Onali, P.L., Strada, S.J., Epstein, P.M., Hersh, E.M. and Thompson, W.J.: Purification of Specific Forms of Low Km Cyclic Nucleotide Phosphodiesterase from Human Leukemic Cells. Fed. Proc. 38:262, 1979.

47. Heindel, J.J., Strada, S.J. and Steinberger, A.: Non-Specific Age Related Decline in the Cyclic AMP Response to Hormones in Isolated Rat Sertoli Cells. Amer. Soc. Androl. 4th Annual Mtg., Houston, Texas, #41, 1979.

48. Heindel, J.J. Steinberger, A. and Strada, S.J.: Characterization of Beta-Adrenergic Receptors in Rat Sertoli Cells. Amer. Soc. Androl., 4th Annual Mtg., Houston, Texas, #42, 1979.

49. Lavis, V.R., Strada, S.J. and Thompson, W.J.: High Extracellular Glucose Inhibits Induction of Hexose Transport by Insulin in Cultured Fibroblasts. Amer. Diabetes Assn., Abst., 1979.

50. Sunkara, P.S., Rao, P.N., Thompson, W.J. and Strada, S.J.: Role of Cyclic Nucleotide Phosphodiesterase (PDE) in the Regulation of Mammalian Cell Cycle. J. Cell Biol. Abst. #43, Vol. 83, 1979.

51. Sarada, K., Strada, S.J., Epstein, P.M. and Thompson, W.J.: Radioimmunoassay of High Affinity Cyclic AMP Phosphodiesterase. Fed. Proc. 39:868, 1980.

52. Martin, M.W., Thompson, W.J. and Strada, S.J.: Calcium-Dependent and Independent Cyclic GMP Phosphodiesterase from Rat Brain. Fed. Proc. 39:868, 1980.

53. Henson, D.B., Onali, P., Strada, S.J. and Thompson, W.J.: Calcium ⁺⁺ Dependent Regulatory Protein Activity in Human Acute Myeloid Leukemia Cells. Fed. Proc. 39:869, 1980.

54. Strada, S.J., Foulkes, J.G., Aitken, A. and Cohen, P.: Mechanism of Inhibition of Protein-Phosphatase-1 by Heat-Stable Inhibitor Proteins. Adv. Cyclic Nucl. Res. 14:673, 1981.

55. Strada, S.J., Foulkes, J.G. and Goris, J.: Inhibition of High Affinity Cyclic AMP Phosphodiesterase by a Protein Isolated from Rabbit Skeletal Muscle. 14th FEBS Meeting, March, 1981.

56. Heindel, J.J., Strada, S.J. and Steinberger, A.: Effect of Cryptorchidism on the Age-Dependent Loss in FSH Responsiveness of Rat Sertoli Cells. Amer. Soc. Androl., March, 1981.

57. Thompson, W.J., Sarada, K. and Strada, S.J.: Immunoassay of Cyclic Nucleotide Phosphodiesterases. Adv. Cyclic Nucl. Res. 14:671, 1981.

58. Strada, S.J., Goris, J., Sarada, K., Chang, L. and Thompson, W.J.: ATPMg-Dependent Inhibition of a High Affinity Cyclic AMP Phosphodiesterase by a Protein Isolated from Rabbit Skeletal Muscle of Dog Kidney. Fed. Proc. 40:1726, 1981.

59. Sarada, K., Strada, S.J. and Thompson, W.J.: Evidence for a Heat Stable Inhibitor of Calmodulin-Stimulated Cyclic GMP Phosphodiesterase from Dog Kidney. Fed. Proc. 40:1727, 1981.

60. Kishi, Y., Kahl, A., Strada, S.J., Thompson, W.J., Skolnick, M.H. and Robison, G.A.: A New Procedure for the Analysis of cAMP Phosphodiesterase (PDE) Activity: Evidence for Two Interconvertible Forms. Fed. Proc. 41:2863, 1982.

61. Foulkes, J.G., Everson, W.V., Strada, S.J., Cohen, P. and Jefferson, L.S.: Antagonistic Effects of Insulin and Isoproterenol on the Activity of Protein Phosphatase Inhibitor-1. Fed. Proc. 41:1454, 1982.

62. McNeely, M.J., Strada, S.J., Pratt, M.L. and Thompson, W.J.: Comparison of Purified Particulate and Cytosolic High Affinity cAMP Phosphodiesterase from Dog Kidney. Adv. Cyclic Nucl. Prot. Phos. Res. 16:428, 1984.

63. Shenolikar, S., Thompson, W.J. and Strada, S.J.: Characterization of a New Form of Ca⁺⁺-Calmodulin Stimulated Cyclic GMP Phosphodiesterase from Bovine Brain. Adv. Cyclic Nucl. Prot. Phos. Res. 16:419, 1984.

64. Friedman, D.L., Thompson, W.J. and Strada, S.J.: Solubilization and Characterization of Particulate Cyclic Nucleotide Phosphodiesterases. Fed. Proc. 42:1847, 1983.

65. Thompson, W.J., Chang, L.K., Shenolikar, S., Pratt, M.L. and Strada, S.J.: Purification of Rabbit Skeletal Muscle High Affinity cAMP Phosphodiesterase Analysis by Western Blot Immunoreactivity. Fed. Proc. 42:1847, 1983.

66. Shenolikar, S., Strada, S.J. and Steiner, A.L.: Regulation of the Phosphorylation State of Protein Phosphate Inhibitor-1 of Rat Liver by Glucagon and Insulin. Fed. Proc. 42: 1801, 1983.

67. Shenolikar, S., Strada, S.J., Huang, H. and Steiner, A.L.: cAMP mediated Protein Phosphorylation: Hormonally Directed Regulation of Protein Phosphatase Inhibitor-1. Amer. Fed. Clin. Res. 31(2), Abst. #529, 1983.

68. Shenolikar, S., Mukku, V., Steiner, A.L. and Strada, S.J.: Dephosphorylation of Protein Phosphatase Inhibitor-1 in Response to Estrogen in Immature Rat Uterus. End. Soc. 1983.

69. Duman, R.S., Strada, S.J. and Enna, S.J.: ACTH or Imipramine Treatment Modify β-Adrenergic Receptor Coupling in Rat Brain Cortex. Soc. Neurosci. 10:1135, 1984.

70. Shenolikar, S., Chang, L., Hanley, R., Strada, S.J. and Thompson, W.J.: Characteristics of High Affinity Cyclic AMP Phosphodiesterase in a Genetically Diabetic Hypoinsulinemic Hamster Model. Fed. Proc. 44:717, 1984.

71. Souness, J.E., Pratt, M.L., Shen, C-C., Thompson, W.J. and Strada, S.J.: Comparison of Immunological, Kinetic and Hormone Sensitive Properties of Type IV cAMP Phosphodiesterase During Differentiation of 3T3-L1 Cells. Fed. Proc. 44:1586, 1984.

72. Souness, J.E., Shen, C-C., Thompson, W.J. and Strada, S.J.: High Affinity Cyclic AMP Phosphodiesterase: Regulation In 3T3-L1 Fibroblasts. J. Ala. Acad. Sci. 55:195, 1984.

73. Shen, C-C., Blackshear, P., Strada, S.J. and Thompson, W.J.: Immunological Studies of Rat Liver Membrane Cyclic AMP Phosphodiesterases. J. Ala. Acad. Sci. 55:204, 1984.

74. Kithas, P.A., Thompson, W.J., Artman, M.F. and Strada, S.J.: Effects of Novel Cardiotonic Agents on Cyclic Nucleotide Phosphodiesterases of Rabbit Heart. Fed. Proc. 44:717, 1985.

75. Thompson, W.J., Black, E.W. and Strada, S.J.: Regulation of Hydrogen Ion Secretion in Rat Gastric Mucosal Parietal Cells Isolated by Centrifugal Elutriation. Fed. Proc. 45:340, 1986.

76. Kithas, P.A., Artman, M.F., Thompson, W.J. and Strada, S.J.: Correlative effects of cardiotonic agents on cyclic nucleotide phosphodiesterases, cyclic AMP dependent protein kinase and contractility in rabbit ventricular muscle. The Pharmacologist 28:129 (1986).

77. Strada, S.J., Shen, C-C. and Thompson, W.J.: Distinct properties of purified kidney high affinity cyclic AMP (cA) phosphodiesterase (Type IV PDE). Adv.Cyc. Nucleo. Res. 21:(1987).

78. Thompson, W.J., Tan, B.H. and Strada, S.J.: Correlation of vanadate/glutathione (V/GSH) activation and cyclic GMP (cG) inhibition of rabbit liver particulate high affinity cyclic AMP (cA) phosphodiesterase (Type IV PDE). Adv. Cyc. Nucleo. Res. 21:(1987).

79. Whalin, M.E., Strada, S.J. and Thompson, W.J.: Purification of membrane-associated cGMP-stimulated cyclic nucleotide phosphodiesterases (Type II PDE) from rabbit brain. Adv. Cyc. Nucleo. Res. 21:(1987).

80. Artman, M., Wicke, J., Kithas, P.A., Crump, D.B. and Strada, S.J.: Myocardial contractile responses to forskolin and milrinone during postnatal maturation. Pediatr. Res. 24(No. 4, Part 2):185A (1987).

81. Garrett, R.L., Jr., Thompson, W.J. and Strada, S.J., Duman, R.S., Nestler, E.J. and Tallman, J.F.: Regional variation of cyclic nucleotide phosphodiesterase isoenzymes in discrete nuclei. Soc. Neurosci. 13(Part 2):903 (1987).

82. Whalin, M.E., Thompson, W.J. and Strada, S.J.: Identification and purification of brain type II phosphodiesterase: A distinct cGMP receptor protein in mammalian brain membranes. Soc. Neurosci. 13(Part 2):902 (1987).

83. Strada, S.J., Garrett, R.L., Kithas, P.A., Shen, C-C., Tan, B.H., Thompson, W.J. and Whalin, M.E.: Biochemical and pharmacological properties of cyclic-nucleotide phosphodiesterases. ABS PAP ACS 193:71 (1987).

84. Kithas, P.A., Artman, M., Thompson,W.J. and Strada, S.J.: High affinity Type IV cAMP phosphodiesterases associated with cardiac sarcoplasmic reticulum: possible site of action for newer cardiotonic drugs. Circulation 76(No. 4, Part 2):IV-457 (1987).

85. Kithas, P.A., Artman, M., Thompson, W.J. and Strada, S.J.: Selectivity of cardiotonic drugs for cardiac high affinity cAMP phosphodiesterases during postnatal maturation. Circulation 76(No. 4, Part 2):IV-456 (1987).

86. Thompson, W.J., Tan, B.H. and Strada, S.J. Characterization of insulin-like activation of rabbit liver microsomal high affinity (Type IV), cAMP phosphodiesterase by vanadyl/glutathione complexes. FASEB J. 2(5):A1041 (1988).

87. Whalin, M.E., Thompson, W.J., Garrett, R.L., Jr. and Strada, S.J.: Regional and subcellular distribution of cyclic nucleotide phosphodiesterase (PDE) isozymes in rat brain. The Pharmacologist 30:A213 (1988).

88. Garrett, R.L., Jr., Thompson, W.J., Whalin, M.E. and Strada, S.J. Differential sensitivity to cyclic nucleotide phosphodiesterase inhibitors in rat brain cortical slices. The Pharmacologist 30:A213 (1988).

89. Whalin, M.E., Scammell, J.G., Thompson, W.J. and Strada, S.J. Regulation of Type II (cGMP-Activatable) Phosphodiesterase in PC12 Cells. Soc. Neurosci. 15:168 (1989).

90. Mayer, D.M., Hanson, A., Strada, S.J., Artman, M. Effects of hemorrhagic shock and retransfusion on catalase and superoxide dismutase activities in rabbits. Clin. Res. 38 (No. 1):40A, 1990.

91. Oquist, N., Strada, S.J., Artman, M. Inotropic responses to selective inhibitors of cGMP-insensitive Type IV cAMP phosphodiesterase in newborn, immature, and adult rabbit myocardium. Clin. Res. 38 (No. 1):40A, 1990.

92. Oquist, N., Strada, S.J., Artman, M. Myocardial contractile responses to selective and non-selective phosphodiesterase (PDE) inhibitors during postnatal maturation in the rabbit. Pediatr. Res. 27 (No. 4, Part 2):23A, 1990.

93. Haynes, J., Kithas, P.A., Bass, J. and Strada, S.J. The role of cyclic nucleotides in hypoxic pulmonary vasoconstriction (HPV). FASEB J. 4:A812, 1990.

94. Mayer, D., Strada, S., Hunter, R. and Artman, M. Effects of poloxamer 188 on survival and hemodynamics in a rabbit model of hemorrhagic shock and transfusion. Circ. Shock 31 (No. 1):33, 1990.

95. Thompson, W.J., Scammell, J.G., Strada, S.J., Hanzel, W. and Repaske, D.R. Identification of Type II (Cyclic-GMP-Stimulatable) Cyclic Nucleotide Phosphodiesterase (CNPDE) mRNA in Rat Pheochromocytoma Cells (PC12). FASEB J.5:A1592, 1991.

96. Haynes, J., Robinson, J., Saunders, L., Taylor, A. E., and Strada, S. J. The Role of cAMP Dependent Protein Kinase in cAMP Mediated Vasodilation. FASEB J.5:A1723, 1991.

97. Artman, M. and Strada, S.J. Inhibition of Cytosolic Phosphodiesterase Activities by HL-725 and SQ-65442 During Perinatal Maturation in the Rabbit. Circulation (no.4):II-383, 1991.

98. Thompson, W.J., Danthuluri, S. and Strada, S.J. Rolipram-sensitive Cyclic Nucleotide Phosphodiesterase Isozyme Regulates Cyclic AMP Metabolism in Pulmonary Microvascular Endothelial Cells. FASEB J. 7:A539, 1993.

99. Ashikaga, T., Strada, S.J. and Thompson, W.J. Altered Expression of Bovine Aortic Endothelial Cell Cyclic Nucleotide Phosphodiesterase Isozymes During Culture. FASEB J. 7:A131, 1993.

100. Lee, A.K., Strada, S.J., Hester, R.B. and Thompson, W.J. Comparison of Rat Pulmonary Microvascular and Bovine Aortic Endothelial Cell Calcium Regulation Using Argon Laser Ion Focal Imaging. FASEB J. 7:A236, 1993.

101. Thompson, W.J., Taylor, A.E., Haynes, J. and Strada, S.J. Cyclic AMP (CA) Production and Reversal of Ischemia-Reperfusion (I-R) Injury by Rolipram (ROL) in Rat Lung. The Pharmacologist, 35: 170, 1993.

102. Diwan, A.H., Honkanen, R.E., Thompson, W.J., and Strada, S.J. Protein Phosphatase Activity in Rat Pulmonary Microvascular Endothelial Cells. FASEB J.: 9:A947, 1995.

103. Diwan, A.H., Honkanen, R.E., Schaeffer, R.C., Jr., Strada, S.J., and Thompson, W.J. Regulation of Microvascular Endothelial Permeability By Protein Phosphatases. FASEB J. 10:A413, 1996.

104. Kelly, J.J., Strada, S.J., and Thompson, W.J. Regulation of Cyclic Nucleotide Phosphodiesterase (CN PDE) Isoenzymes In Pulmonary Microvascular Endothelial Cells (PMEC): Induction of New Isoforms By Rolipram and Forskolin. FASEB J. 10:A679, 1996.

105. Schaeffer, R.C., Jr., Klein, J.D., O’Neill, W.C., Diwan, A.H., Strada, S.J. and Thompson, W.J. Calyculin A Causes Endothelial Monolayer Barrier Failure Without Stress Fiber Formation. FASEB J. 10:A680, 1996.

106. Kelly, J.J. Strada, S.J. and Thompson, W.J. Effect of Ionomycin on Pulmonary Microvascular Endothelial Cell Permeability; Inhibition of Cyclic Nucleotide PDE4. J. Mol. Cell. Cardiol. 29:A218, 1997.

107. Sawmiller, D.R., Strada, S.J., Thompson, W.J. and Townsley, M.I. Lung Cyclic Nucleotide Phosphodiesterease (PDE) Activity and Isoform Distribution After Heart Failure. FASEB J. 14:A588, 2000.

108. Zhu, B. Strada, S.J., Vemavarapu, L., and Thompson, W.J. Inhibition of the Expression of Phosphodesterase 5 by Antisense Inhibits the Growth of Human Colon Carcinoma (HT-29) Cells in Culture. FASEB J. 15:A924, 2001.

109. Zhu, B., Vemavarapu, L., Pamukcu, R., Strada, S.J., and Thompson, W.J. Stable Expression of Phosphodesterase (PDE) 5 Antisense in Human Colon Tumor HT29 Cell is Associated with Delayed G2/M Cell Cycle Progression. AACR Annual Meeting, San Francisco, California, April 2002.

INVITED RESEARCH SEMINARS

UTMS San Antonio - Departments of Pharmacology & Anatomy (1972)
Baylor College of Medicine, Dept. of Cell Biology (November, 1974)
University of Houston, Dept. of Pharmacology (April, 1975)
University of Missouri at Columbia, Dept. of Pharmacology (Sept., 1975)
University of Missouri at Columbia, Dept. of Pharmacology (Oct., 1976)
Medical College of Pennsylvania, Dept. of Pharmacology (December, 1976)
University of South Alabama, Dept. of Pharmacology (December, 1976)
Baylor College of Medicine, Dept. of Cell Biophysics (March, 1977)
University of Texas at Galveston, Dept. of Pharmacology (Sept., 1977)
University of Arkansas Medical Center, Dept. of Pathology (February, 1978)
University of Dundee, Department of Biochemistry (1979)
University of Dundee, Department of Pharmacology (1980)
University of Leeds, Department of Biochemistry (1980)
NIMH, Laboratory of Preclinical Pharmacology (December, 1980)
Rockefeller University, Department of Cell Biology (December, 1980)
Baylor College of Medicine, Department of Pharmacology (January, 1981)
University of South Alabama College of Medicine (October, 1982)
University of Tennessee Health Sciences, Department of Pharmacology (December, 1983) Ciba-
Geigy, Division of Biology Research, Summit, New Jersey (December, 1983)
University of Massachusetts School of Medicine, Department of Biochemistry (March, 1984)
University of West Virginia, School of Medicine, Department of Biochemistry (September, 1985)
Louisiana State University, School of Medicine, Department of Pharmacology (October, 1985)
Emory University, School of Medicine, Department of Pharmacology (December, 1985)
University of Mississippi, School of Medicine, Department of Pharmacology (May, 1986)
Medical College of Pennsylvania, Department of Pharmacology (June, 1987)
Ayerst Pharmaceutical Corp., Dept. of Biochemical Pharmacology (Sept. 1987)
University of New Mexico, Department of Pharmacology (March, 1988)
Tokyo Medical and Dental University, IIIrd Department of Internal Medicine, Tokyo, Japan (July, 1988).
Schering-Plough Pharmaceutical Corp., Department of Cardiovascular Pharmacology (January, 1989).
Wadsworth Center For Laboratories and Research, Albany, New York (May, 1989)
University of South Florida, School of Medicine, Department of Pharmacology (Sept. 1990)
State University of New York at Stony Brook, School of Medicine, Department of Pharmacological Sciences (March, 1998)

GUEST LECTURESHIPS AND PRESENTATIONS

Houston Chapter of Society for Neurosciences (1972)

Houston Pharmacology Society - Inaugural Meeting (1972)

University of Houston, Pharmacology, Lecturer in Graduate Course on Mechanisms of Hormone Action (1974).

University of Texas Systems Cancer Center, Basic Science Study Section in Pediatrics (Residency program, March 1975)

University of Houston, Biochemistry and Biophysics, Lecturer in Advanced Course in Neurochemistry, November 1975.

University of Missouri at Columbia, Department of Pharmacology (April 1976) Series of 5 lectures on Psychopharmacology given to 2nd year medical students.

Endocrinology Grand Rounds (UT/Baylor), May 1977, "Catecholamines and pheochromacytoma" together with W. Kirkendall, M.D., Chief, Division of Hypertension

Workshop with Wm S. Fields, M.D., Chairman, Neurology UTMSH six sessions on clinical pharmacology, evaluation, design, moral and ethical considerations of drug studies,part of Univ. Houston Pharmacology course given to FDA inspectors, January, 1978.

UTMSH Psychiatry Continuing Education Symposium on Geriatric Somatopsychiatry, presented lecturer on "Neuropsychiatric Side Effects of Antiparkinsonian Drugs", January, 1978.

Discussion leader in Neurology Resident Conferences (UTMSH), April, 1978.

Diabetes Study Program, lecturer, 1980, "Protein phosphorylation as a mediator of hormone action".

Lecturer on Adrenergic Receptors, Neurology Resident Series (UTMSH), 1982.

Grand Rounds, Department of OB/GYN, University of South Alabama, "Adrenergic Receptor Regulation", October, 1985.

Searcy Hospital Psychiatry Staff, "Mechanism of Action of Antipsychotic Drugs", November, 1986.

Grand Rounds, Department of Surgery, University of South Alabama, "Second Messengers and Hormone Action", December, 1986.

Lecture, Department of Neurology, University of South Alabama, "How Does Ritalin Work?", March, 1988.

Grand Rounds, Department of Psychiatry, University of South Alabama, "Novel Mechanisms for Antidepressant Drugs", May, 1990.

Lecturer, "Pharmacology of Receptors", Neurology Residents, University of South Alabama, March, 1991.

Speaker, "Insights into Collegiate Athletics: Similiarities Between the AAMC and the NCAA", Annual Banquet of AOA Honor Medical Society, May, 1991, University of South Alabama, College of Medicine.

ADHOC REVIEWER

American Journal of Physiology
American Journal of the Medical Sciences
Analytical Biochemistry
Biochemistry
Biochemical Pharmacology
Biochimica Biophysica Acta - Brain Research
Cardiovascular Pharmacology
Clinical and Experimental Pharmacology and Physiology
Endocrinology
Life Sciences
Cancer Research
Circulation Research
European Journal of Biochemistry
FASEB Journal
FEBS Letters
Hormone and Metabolic Research
Journal of Biological Chemistry
Journal of Laboratory and Clinical Medicine
Journal of National Cancer Institute
Journal of Neurochemisty
Journal of Pharmacology and Experimental Therapeutics
Molecular and Cellular Endocrinology
Molecular Pharmacology
Nature
Neuropharmacology
Neuroscience Research
Peptides
Science

SERVICE ACTIVITIES

THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON COMMITTEES:
Health Science Center Committee for the Protection of Human Subjects in Research (1974 - 1983)
Committee on Graduate Studies in Pharmacology (Chairman, 1975 - 1977)
Internal Evaluation Committee for Graduate School (1976 - 1977)
Search Committee for Graduate School Dean of Biomedical Sciences (1977)

THE UNIVERSITY OF TEXAS MEDICAL SCHOOL AT HOUSTON COMMITTEES:
General Stores Committee (1972-1973)
Curriculum Subcommittee on Neurosciences (1972-1975)
Preceptorship Evaluation Committee (Chairman, 1974)
Faculty Appointments, Promotions and Tenure Committee (1977-1983)
Committee on Committees (1980-1981)
General Research Support Committee for Biomedical Research (1974 - 1977)
(Chairman, 1975-1977)
Basic Science Council (1981-1982)
Analytical Chemistry Center Advisory Committee (1981-1982)
Ad hoc Committee on Computers in Medical Education (Chairman, 1982-1983)

UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE COMMITTEES:
Committee for the Protection of Human Subjects (1985-1987)
Executive Council (1983-Present)
Patent Committee (1983-1989)
Curriculum Committee (1983-1985)
Faculty Appointments, Promotions and Tenure Committee (1983-1988)
Basic Science Interdisciplinary Seminar Committee, Chairman (1985-1986)
Member, Search Committee, Director of Mass Spectrometry Center (1986)
Member, Search Committee, Dean of College of Medicine (1986-87)
Member, Search Committee, Endocrinologist, Department of Medicine (1987)
Chairman of Search Committee, Department of Cell Biology and Anatomy Chairperson (1987-88)
Chairman of Search Committee, Department of Surgery Chairperson (1988)
Advisory Committee, Biopolymer Center (1988-1993)
Medical School Admissions Committee (1987-1990; Chairman 1989-90)
Committee on Committees (1987-1990)
Co-Chair of Search Committee, Dean of College of Medicine (1990)
Member, Search Committee, Department of Biochemistry Chairperson (1991)
Chairman of Search Committee, Department of Psychiatry Chairperson (1992)
Distinguished Scientist Seminar Committee, Chairman (1986-87, 1992-94)
Member, Search Committee, Director of Comprehensive Sickle Cell Center (1992-93)
Co-Chair, LCME Self-Study Accreditation (1994-95)
South Alabama Medical Science Foundation, Board of Directors (1983-Present)
South Alabama Medical Science Foundation, Secretary (1988-1993)
South Alabama Medical Science Foundation, President (1994-Present)
Chairman of Search Committee, Department of Physiology Chairperson (2001-02)
Member, Search Committee, Department of OB/Gyn Chairperson (2001-02)
Co-Chair, LCME Self Study Accreditation (2001-02)

UNIVERSITY-WIDE COMMITTEES:
Advisory Committee, Biology/Basic Medical Sciences Master's Program (1986-1988)
Faculty Grievance Committee (1986-1991)
25th Anniversary Committee (1988-1989)
Faculty Athletics Representative, Sunbelt Conference and NCAA (1990-1997)
Southern Association Accreditation (Institutional Self Study):
Chair of Intercollegiate Athletics Committee (1991-1992)
Medical Affairs Planning Committee (1992-1994)
NCAA Compliance and Certification Committee (1993-1997 )
University Athletics Council (1990-1997); Chair (1993-1997)
Steering Committee, NCAA Certification Self-Study (1994-1996)
Chair- Search Committee for Head Men's Basketball Coach (1995)
Chair- Search Committee for Head Women's Basketball Coach (1995)
Athletic Hall of Fame Selection Committee (1995- )
Professional Sports Counseling Panel (1995-1997 )
University Library Committee (1996- )
Animal Care and Use Committee (1993- )
University Committee on Cost Accounting Standards (2000- )
Campus Director, Alabama Space Grant Consortium (2001- )

STATE-WIDE COMMITTEES:
Alabama Board of Medical Scholarship Awards (1996- 2000)
Alabama Space Grant Consortium Committee (2001- )

RESEARCH TRAINEES AND THEIR CURRENT POSITION

Postdoctoral Fellows
W.J. Pledger, Ph.D. (1973-76)
Associate Director for Basic Research
H. Lee Moffitt Cancer Center and Research Institute
University of South Florida College of Medicine
Tampa, Florida

Marie Hintz, Ph.D. (1975-77)
Research Associate, Department of Pediatrics
University of California at San Diego

Paul Epstein, Ph.D. (1976-79)
Associate Professor of Pharmacology
University of Connecticut School of Medicine

Pier Luigi Onali, M.D. (1978-79)
Research Professor, Department of Neuroscience
University of Caligiri, Caligiri, Sardenia

Mary L. Pratt, Ph.D. (1981-83)
Research Associate, Department of Biochemistry
University of Texas Medical School at Houston

Yukio Kishi, M.D. (1982)
Associate Professor,IIIrd Department of Internal Medicine
Tokyo Medical and Dental University
Tokyo, Japan

John Souness, Ph.D. (1982-84)
Staff Scientist, Biological Research Department
Rhone-Poulene Ltd.
Dagenham, Essex, England

Eric Black, Ph.D. (1984-87)
Instructor, Department of Pharmacology
University of Texas Medical Branch
Galveston, Texas

Robert Garrett, Jr., Ph.D. (1986-88)
Associate Professor of Pharmacal Sciences
Pharmacology Division, Campbell University
School of Pharmacy, Buies, North Carolina

Takashi Ashikaga, M.D. (1991-93)
Associate Professor
Department of 1st Internal Medicine
Yokohama Minami Kyousai Hospital
Kanagawa, Japan

Visiting Professors
Isao Morishima, Ph.D. (1978)
Professor of Biochemistry
Tottori University, School of Agricultural Chemistry
Tottori, Japan

Shirish Shenolikar, Ph.D. (1982-83)
Professor of Pharmacology
Duke University School of Medicine

George Cehovic, M.D. (1985-87)
Director, Scientific Affairs
Pharmakon Research International, Inc.
Waverly, Pennsylvania

James B. Polson (1994)
Professor of Pharmacology
University of South Florida
College of Medicine
Tampa, Florida

Graduate Students (As Mentor)
Michael W. Martin, Ph.D., 1981
Associate Professor, Department of Pharmacology
Texas College of Osteopathic Medicine
Fort Worth, Texas

Philip A. Kithas, Ph.D., 1987, M.D., 1990
Associate Professor, Department of Internal Medicine
College of Medicine
University of Utah
Salt Lake City, Utah

A. Hafeez Diwan, M.D., Ph.D., 1997
Fellow in Dermatopathology
University of Alabama at Birmingham
Birmingham, Alabama

Student Advisory and Supervisory Committees:

David Jones, UTGSBS, (San Antonio, outside examiner, Ph.D., 1974) (Pharmacology)
Ronald Browne, UTGSBS, Ph.D., 1975 (Neuroscience)
James Gum, UTGSBS, M.Sc., 1976 (Biomedical Science)
Chester Davis, UTGSBS, Ph.D., 1975 (Biomedical Science)
William Hiatt (Medical College of Pennsylvania, outside examiner, Ph.D.1977) (Pharmacology)
Gregory King (Baylor, Ph.D. 1979) (Physiology)
Rex Hinshaw, UTGSBS, M.Sc., 1979 (Biomedical Sciences)
Peter Silverman, UTGSBS, Ph.D., 1977 (Neuroscience)
Robert McClung, UTGSBS, M. Sc., 1975 (Neurobiology)
Ann Marie Hedberg, UTGSBS, M. Sc., 1982 (Biomedical Sciences)
Daniel Burnham, UTGSBS, Ph.D., 1980 (Physiology)
Hsin-Li Lin, UTGSBS, Ph.D., 1980 (Reproductive Biology)
Darlene Antalis, UTGSBS, M. Sc., 1978 (Reproductive Biology)
Mary McKenna, UTGSBS, M.Sc., 1978 (Neuroscience)
John Ferkany, UTGSBS, Ph.D., 1980 (Pharmacology)
Michael Martin, UTGSBS, Ph.D., 1981 (Pharmacology)
James Marchand, UTGSBS, Ph.D., 1980 (Neurobiology)
Robert George, UTGSBS, Ph.D., 1984 (Neurobiology)
Keith Wilner, UTGSBS, Ph.D., 1984 (Pharmacology)
Ron Duman, UTGSBS, Ph.D., 1985 (Pharmacology)
Philip Kithas, USA, Ph.D., 1987 (Pharmacology)
Mahmood Seyed Mozaffari, USA, Ph.D., 1988 (Pharmacology)
Gregory McKelvey, USA, Ph.D., 1989 (Biochemistry)
Simon Allo, USA, Ph.D., 1989 (Pharmacology)
Caroline Burton (Univ. of Mississippi, outside examiner, Ph.D., 1989) (Pharmacology)
Michael Whalin, USA, Ph.D., 1990 (Pharmacology)
Stephen A. Robicsek (University of South Florida, outside examiner, Ph.D., 1990) (Pharmacology)
John Crow, USA, Ph.D., 1991 (Pharmacology)
Michelle Duffourc, USA, Ph.D., 1993 (Pharmacology)
Marilyn Thompson, USA, Ph.D., 1994 (Pharmacology)
Scott Boerth, USA, Ph.D., 1995 (Pharmacology)
Wei Song, USA, Ph.D., 1995 (Pharmacology)
Nancy Johnston Boerth, USA, Ph.D., 1996 (Pharmacology)
Letetia Jones, USA, Ph.D., 1997 (Pharmacology)
Yan Xu, USA, Ph.D., 1997 (Pharmacology)
Ling Zhou, USA, Ph.D., 1997 (Pharmacology)
Hafeez Diwan, USA, Ph.D., 1997 (Pharmacology)
Cherry Ballard-Croft, USA, Ph.D., 1998 (Pharmacology)