Wilson, Glenn L., Ph.D.

Research Interests

A major focus of the studies conducted in this laboratory is on the role of environmental factors in the etiologies of the various forms of diabetes mellitus. Present work is centered on the mechanisms by which xenobiotics can interact with insulin producing pancreatic beta cells to either kill these cells directly, to elicit an inflammatory response against these cells which results in their destruction, or to cause their functional impairment. Currently, new molecular biological technology is being employed to study the damage and repair in specific sequences of both nuclear and mitochondrial DNA. Of particular interest is how specific lesions are repaired and what are some of the factors that may prevent this repair and cause alterations in DNA which ultimately may produce diabetes mellitus.

A second area of interest is in the normal process of aging. This work is designed to test the hypothesis that it is the accumulation of damage within DNA that causes some of the phenotypes associated with aging. Specifically, the objective of this work is to determine how DNA repair mechanisms change with aging. Repair in both the nucleus and the mitochondria is being evaluated in cells from individuals of differing age, in cells aged in tissue culture and in cells from individuals with genetic syndromes of premature aging. When successfully completed this work should provide new insights into how the natural process of aging can be slowed or how the consequences of its various manifestations can be lessened.

Phillips University, Enid, Oklahoma
1967 - 1969

University of New Mexico, Albuquerque, NM
1971, B.S. Biology

University of Illinois at the Medical Center, Chicago, IL
1976, Ph.D. - Anatomy

Harvard University, Boston, MA
1976 - 1978, Post Doc

University of Vermont, Burlington, VT
1978 - 1980, Post Doc

PROFESSIONAL EXPERIENCE

PROFESSIONAL HONORS

1985 1990 NIH Research Career Development Award
1980 Juvenile Diabetes Foundation Fellowship
1977 1980 National Institutes of Health Postdoctoral Fellowship
1971 1972 University of Illinois Fellowship
1970 1971 Associated Western Universities Fellowship
1967 International Science Fair Finalist

EDITORIAL BOARDS

Clinical Science

JOURNAL REVIEWS

American Journal of Pathology
American Journal of Physiology
Biochemistry
Carcinogenesis
Cancer Research
Cell Biology and Toxicology
Chemical Research and Toxicology
Clinical Science
Diabetes
Diabetologia
Endocrine
Endocrinology
Free Radical Biology & Medicine
Journal of Biological Chemistry
Journal of Clinical Investigation
Journal of Neurochemistry
Journal of Pharmacology and Experimental Therapeutics
Life Sciences
Mutation Research
Neoplasia
Nucleic Acids Research
Oncogene
Proceedings of the National Academy of Sciences, U.S.A.

CONSULTANTSHIPS

TEACHING ASSIGNMENTS

COMMITTEE ASSIGNMENTS

Curriculum Committee (Graduate School)
Executive Committee (Graduate School)
Student Evaluation and Promotion Committee (Graduate School)
Faculty Evaluation and Promotion Committee (Medical School)
Faculty Student Liaison Committee (Medical School)
Curriculum Committee (Medical School)
Executive Committee (Medical School)
Student Evaluation and Promotion Committee (Medical School)
M.D./Ph.D. Program Committee
Human Protection Committee
Self Study Task Force
Biomedical Library Advisory Committee (Chairman)
Committee for the Revision of the Graduate Catalog (University)
University Research Committee
Committee for the Revision of the First Year Medical School Curriculum (Chairman)
Student Research Day (Chairman)
Biomedical Forum (Chairman)
Mass Spectrometry Core Facility Steering Committee (Chairman)
Faculty Recruitment Committee, Department of Structural and Cellular Biology (Chairman)
Committee on Committees

GRADUATE STUDENT DIRECTION

CURRENT GRANT SUPPORT

NIH; ES03456; Environmental Beta Cell Toxins: Mechanisms of Action; G.L. Wilson, PI; $225,000 (DC), 1st year; $1,125,000 total support; 7/1/01-6/30/06.

NIH; AG19602; Oxidative Damage and Repair in Neuronal mtDNA; G.L. Wilson, PI; $166,319 (DC), 1st year; $1,275,945 total support; 9/30/00-8/31/05.

NIH; ES05865; Repair of DNA Damage Induced by Environmental Agents; S.L. LeDoux, PI; G.L. Wilson, Co-Investigator; $200,000 1st year; $1,000,000 total support; 7/1/01-6/30/05.

NIH; HL58234; DNA Lesions and Gene Expression in Hypoxic Lung Disease; M.N. Gillespie, PI; G.L. Wilson Co-investigator; $171,023 1st year; $913,308 total support; 07/01/98-6/30/03.

PENDING GRANT SUPPORT

NIH; Oxidative Stress in Neurons: Role of Mitochondrial DNA,11/30/0812/01/2003, (Total Award) $1,125,000, (First Year) $225,000.

PAST GRANT SUPPORT

DOD (US Army Concept Award); Altering Cell Survival by Modulating Levels of Mitochondrial DNA Repair Enzymes; total award $50,000 (DC); 9/01/00-8/31/02.

NIH; RO1 (CA69872, Years 1-5) Subcontract with Ohio State; Gene Specific Mutations in Skin Induced by Peroxynitrite; F.M. Robertson, P.I.; G.L. Wilson, PI subcontract; $68,792, 1st year; $381,115 total support; 4/1/97-3/31/02.

NIH; ES05865; Repair of DNA Damage Induced by Environmental Agents; S.L. LeDoux, PI; G.L. Wilson, Co-Investigator; $118,309 1st year; $476,437 total support; 7/1/96 - 6/30/00.

NIH; ES03456; Environmental Beta Cell Toxins: Mechanisms of Action; G.L. Wilson, PI; $149,709, 1st year; $810,872 total support; 7/1/95-6/30/01.

NIH; AG12442; The Effects of Aging on DNA Repair; G.L. Wilson, PI; $157,981, 1st year; $938,896 total support; 4/01/95-3/31/00.

NIH; DK44993; Effect of Diabetes on Mitochondrial Anion Transporters; R.S. Kaplan, PI; G.L. Wilson, Co-Investigator; $118,754, 1st year; $497,792 total support; 7/1/93-6/30/97.

Juvenile Diabetes Foundation; Student Summer Research Program, G.L. Wilson, PI; $15,000; 1993.

NIH; ES03456; Environmental Beta Cell Toxins: Mechanisms of Action; G.L. Wilson, PI; $134,738, 1st year; $420,598 total support; 7/1/92-6/30/95.

Juvenile Diabetes Foundation; Student Summer Research Program, G.L. Wilson, PI; $10,000; 1992.

Juvenile Diabetes Foundation; Student Summer Research Program, G.L. Wilson, PI; $12,500; 1991.

Pfizer Pharmaceutical; Effect of Sulfonylureas on the Hearts of Rats with Streptozotocin-Induced Noninsulin-Dependent Diabetes Mellitus, B.A. Warner, S.W. Schaffer and G.L. Wilson, Investigators; $40,000; 1990 - 1993.

Juvenile Diabetes Foundation; Student Summer Research Program, G.L. Wilson, PI; $25,000; 1990.

American Diabetes Association; Spectrin and the Regulation of Insulin Secretion; S.R. Goodman, PI; G.L. Wilson, Co-Investigator; $40,000 1st year; $80,000 total support; 7/01/90 -6/30/92.

Juvenile Diabetes Foundation; Student Summer Research Program, G.L. Wilson, PI; $25,000; 1989.

NIH; DK36440; Myocardial Metabolic Abnormalities in Non Insulin Dependent Diabetes Mellitus; S.W. Schaffer, PI; G.L. Wilson, Co Investigator; $101,292, 1st year; $319,196, total support; 7/1/89 6/30/93.

Juvenile Diabetes Foundation; Student Summer Research Program, G.L. Wilson, PI; $25,000; 1988.

NIH; ES03456; Environmental Beta Cell Toxins: Mechanisms of Action; G.L. Wilson, PI; 60% effort; $99,628, 1st year; $601,204 total support; 7/1/87 6/30/92.

NIH; AM36440; Myocardial Metabolic Abnormalities in Non Insulin Dependent Diabetes Mellitus; S.W. Schaffer, PI; G.L. Wilson, Co Investigator; 10% effort; $67,582, 2nd year; $207,552, total support; 1/1/86 12/31/88.

NIH; ES00150; Research Career Development Award; Environmental Beta Cell Toxins; G.L. Wilson, PI; 90% effort; $250,000, total support; 9/27/85 8/31/90.

NIH; ES03456; Environmental Beta Cell Toxins: Mechanisms of Action; G.L. Wilson, PI; 50% effort; $248,289, total support; 7/1/84 6/30/87.

American Diabetes Association; Diabetic Retinopathy: The Role of Monoamide Systems: R.B. Chronister, PI; G.L. Wilson, Co Investigator, $49,150, total support; 9/1/84 8/31/86.

NIH; New Investigator Award; ES03066; N Nitroso Compounds in Insulin Dependent Diabetes; G.L. Wilson, PI; 50% effort, $106,495, total support; 3/1/82 2/28/85.

American Diabetes Association; $10,000; 1981 1983.

Kroc Foundation; $10,000; 1980 1982.

PUBLICATIONS

Matsubara E, Bryant-Thomas T, Pacheco Quinto J, Henry TL, Poeggeler B, Herbert D, Cruz-Sanchez F, Chyan YJ, Smith MA, Perry G, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson GL, Ghiso J, Williams C, Refolo LM, Pappolla M. Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer’s disease. J Neurochem. 85(5):1101-1108, 2003.

Druzhyna, N.M., Hollensworth S.B., Kelley M.R.,Wilson G.L. and LeDoux, S.P. Targeting Human 8-Oxoguanine Glycosylase to Mitochondria of Oligodendrocytes Protects Against Menadione-Induced Oxidative Stress. Glia 42(4):370-378, 2003.

Shokolenko, I.N., Alexeyev, M.F., Robertson, F.M., LeDoux, S.P., and Wilson, G.L. The expression of exonuclease III from E.coli in mitochondria of breast cancer cells diminishes mitochondrial DNA repair capacity and cell survival after oxidative stress. DNA Repair 2(5):471-482, 2003.

Grishko, V., Killilea, D.W., Ault-Ziel, K., LeDoux, S.P., Wilson, G.L., and Gillespie, M.N. Formation and repair of oxidant-mediated DNA modifications in hypoxic pulmonary artery smooth muscle cells. Amer. J. Physiol.: Lung Cell Molec. Physiol. (Submitted 2003).

Bozner P, Wilson GL, Druzhyna NM, Bryant-Thomas TK, LeDoux SP, Pappolla MA. Deficiency of chaperonin 60 in Down’s syndrome. J Alzheimers Dis. 4(6):479-486, 2002.

Rachek, L.I., Grishko, V.I., Musiyenko, S.I., Kelley, M.R., LeDoux, S.P., and Wilson, G.L. Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria. J. Biol. Chem. 277:44932-44937 (2002).

Dobson AW, Kelley MR, Wilson GL, LeDoux SP. Targeting DNA repair proteins to mitochondria. Methods Mol Biol 197:351-362, 2002.

Dobson, A.W., Grishko, V., LeDoux, S.P., Kelley, M.R., Wilson, G.L., and Gillespie, M.N. Enhanced mitochondrial DNA repair capacity protects pulmonary artery endothelial cells of oxidant-mediated death. Amer. J. Physiol.: Lung Cell Molec. Physiol. 283:205-210 (2002).

Shokolenko, I., Oberyszyn, T.M., D’Ambrosio, S.M., Saavedra, J.E., Keefer, L.K., LeDoux, S.P., Wilson, G.L., and Robertson, F.M. Protection of human keratinocyte mtDNA by low-level nitric oxide. Nitric Oxide 5(6):555-560 (2001).

LeDoux, S.P., and Wilson, G.L. Base excision repair of mitochondrial DNA damage in mammalian cells. Prog. Nucleic Acid Res. Mol. Biol. 68:273-284 (2001).

Grishko, V., Solomon, M., Breit, J.F., Killilea, D.W., LeDoux, S.P., Wilson, G.L., and Gillespie, M.N. Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene. FASEB Journal 15:1267-1269 (2001).

Grishko, V., Solomon, M., Wilson, G.L., LeDoux, S.P., and Gillespie, M.N. Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes. Am. J. Physiol. Lung Cell. Mol. Physiol. 280:L1300-L1308 (2001).

Wang, G., Chen, Z., Zhang, S., Wilson, G.L., and Jing, K. Detection and determination of oligonucleotide triplex formation-mediated transcription-coupled DNA repair in HeLa nuclear extracts. Nucleic Acids Res. 29:1801-1807 (2001).

Dobson, A.W., Xu, Y., LeDoux, S.P., and Wilson, G.L. Enhanced mtDNA repair and cellular survival following oxidative stress by targeting the hOGG repair enzyme to mitochondria” J. Biol. Chem. 275:37518-37523 (2000).

Druzhyna, N., Smulson, M.E., LeDoux, S.P., and Wilson G.L. Poly (ADP-ribose) polymerase facilitates the repair of N-methylpurines in mtDNA. Diabetes 49:1849-1855 (2000).

Hollensworth B.S., Shen C., Sim, J.E., Spitz, D.R., Wilson, G.L., and LeDoux, S.P. Glial cell type specific responses to menadione-induced oxidative stress. Free Radical Biology and Medicine 28:161-174 (2000).

Pappolla, M.A., Chyan Y.J., Poeggler, B., Frangione B., Wilson, G.L. Ghiso, J., and Reiter R.J. An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer’s Disease. J. Neural Transmisson 107:203-231 (2000).
Grishko, V.I., Druzhyna, N., LeDoux, S.P. and Wilson, G.L. Nitric oxide-induced damage to mtDNA and its subsequent repair. Nucleic Acids Res. 27:4510-4516 (1999)

Pappolla, M.A., Chyan, Y.J., Poeggeler, B., Bozner, P., Ghiso, J., LeDoux, S.P., and Wilson, G.L. Alzheimer β protein mediated oxidative damage of mitochondrial DNA: Prevention by melatonin. J. Pineal Res. 27:226-229 (1999).

LeDoux, S.P., Driggers W.J., Hollensworth, B.S., and Wilson, G.L. Repair of alkylation and oxidative damage in mitochondrial DNA. Mut. Res. 434:149-159 (1999).

Druzhyna, N., Nair, R.G., LeDoux, S.P., and Wilson, G.L. Defective repair of oxidative damage in mitochondrial DNA in Down’s Syndrome. Mutat. Res. 409:81-89 (1998).

LeDoux, S.P., Shen, C., Grishko, V.I., Fields, P.A., Gard, A.L., and Wilson, G.L. Glial cell-specific differences in response to alkylation damage. Glia 24:304-312 (1998)

Gillespie, M.N., Killilea, D.W., Solomon, M., Babal, P., LeDoux, S.P., and Wilson, G.L. Hypoxia causes oxidant lesions in the rat pulmonary artery smooth muscle cell VEGF gene; Potential link to VEGF mRNA expression. Chest 114:45 (1998).

Bozner, P., Grishko, V., LeDoux, S.P., Wilson, G.L., and Pappolla, M.A, The amyloid β-protein induces oxidative damage of mitochondrial DNA. J. Neuropathol. Exp. Neurol. 56:1356-1362 (1997).

Driggers, W.J., Holmquist, G.P., LeDoux, S.P., and Wilson, G.L. Repair of oxidative damage within mitochondrial DNA at the strand- and nucleotide-specific levels. Nucleic Acids Res. 25:4362-4369 (1997).

Grishko, V.I., LeDoux, S.P., and Wilson, G.L. The repair of oxidative damage in nuclear DNA sequences with different transcriptional activities is homogeneous. Mutation Res. 334:73-80 (1997).

Zimmer, D.B., Chessher, J., Wilson, G.L., and Zimmer, W.E. S100A1 and S100B expression and target proteins in type I diabetes. Endocrinology 138:5176-5183 (1997).

Meng, Y.X., Wilson,G.L., Avery, M.C., Varden C.H., and Balczon, R. Suppression of the expression of a pancreatic β-cell form of the kinesin heavy chain by antisense oligonucleotides inhibits insulin secretion from primary cultures of mouse β-cells. Endocrinology 138:1979-1987 (1997).

Wilson, G.L., Patton, N.J., and LeDoux, S.P. Mitochondrial DNA in β-cells is a sensitive target for damage by nitric oxide. Diabetes 46:1291-1295 (1997).

LeDoux, S.P., Williams, B.A., Hollensworth, B.S., Shen, C., Thomale, J., Rajewsky, M.F., Brent, T.P., and Wilson, G.L. Glial cell-specific differences in repair of O6-methylguanine. Cancer Res. 56:5615-5619 (1996).

Ray, L.S., Chatterjee, S., Berger, N.A., LeDoux, S.P., and Wilson, G.L. Catalytic activity of poly (ADP-ribose) polymerase is necessary for repair of N-methylpurines in nontranscribed, but not transcribed, nuclear DNA sequences. Mutation Res. 363:105-114 (1996).

Driggers, W.J., Grisko, V.I., LeDoux, S.P., and Wilson, G.L. Defective repair of oxidative damage in mitochondrial DNA of an XP-A cell line. Cancer Res. 56:1262-1266 (1996).

Shen, C.C., Wertelecki, W., Driggers, W.J., LeDoux, S.P., and Wilson, G.L. Repair of mitochondrial DNA damage induced by Bleomycin in human cells. Mutation Res. 337:19-23 (1995).

Driggers, W.J., LeDoux, S.P., and Wilson, G.L. Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells. J. Biol. Chem. 268:22042-22045 (1993).

Nelson, J.W., LeDoux, S.P., and Wilson, G.L. Repair of O6-methylguanine in rat pancreatic beta cells following exposure to N-methyl-N-nitrosourea. Diabetes 42:1187-1194 (1993).

Schaffer, S.W., Warner, B.A., and Wilson, G.L. Effects of Chronic Glipizide treatment on the NIDD heart. Horm. Metab. Res. 25:348-352 (1993).

LeDoux, S.P., Patton, N.J., Avery, L.J., and Wilson, G.L. Repair of N-methylpurines in the mitochondrial DNA of xeroderma pigmentosum complementation Group D cells. Carcinogenesis 14:913-917 (1993).

Schaffer, S.W., and Wilson, G.L. Factors contributing to the insulin and mechanical dysfunction that develops in the hearts of Wistar rats with SZ-induced. Diabetologia 36:195-199 (1993).

LeDoux, S.P., Wilson, G.L., Beecham, E.J., Stevnsner, T, Wassermann, K., and Bohr, V.A. Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells. Carcinogenesis 13:1967-1973 (1992).

Plakas, S.M., Loveland, P.M., Bailey, G.S., and Wilson, G.L. Tissue disposition and excretion of 14C-labelled aflatoxin B1 after oral administration in Channel Catfish. Fd. Chem. Toxic. 29:805-808 (1991).

Kaplan, R.S., Mayor, J.A., Blackwell, R., Wilson, G.L., and Schaffer, S.W. Functional levels of mitochondrial anion transport proteins in non-insulin-dependent diabetes mellitus. Molec. Cell. Biochem. 107:79-86 (1991).

Allo, S.N., Lincoln, T.M., Wilson, G.L., Green, F.J., Watanabe, A.M., and Schaffer, S.W. Noninsulin-dependent diabetes induced defects in cardiac cellular calcium regulation. Am. J. Physiol. 260:C1165-1171 (1991).

Kaplan, R.S., Mayor, J.A., Blackwell, R., Maughon, R.H., and Wilson, G.L. The effect of insulin supplementation on diabetes-induced alterations in the levels of functional mitochondrial anion transport proteins. Arch. Biochem. Biophys. 287:305-311 (1991).

Pettepher, C.C., LeDoux, S.P., Bohr, V.A., and Wilson, G.L. Repair of alkali labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin. J. Biol. Chem. 266:3113-3117 (1991).

LeDoux, S.P., Thangata, M., Bohr, V.A., and Wilson, G.L. Heterogeneous repair of methylnitrosourea-induced alkali labile sites in different DNA sequences. Cancer Res. 51:775-779 (1991).

LeDoux, S.P., Patton, N.J., Nelson, J.W., Bohr, V.A., and Wilson, G.L. Preferential DNA repair of alkali-labile sites within the active insulin gene. J. Biol. Chem. 265:14875-14880 (1990).

Kaplan, R.S., Oliveira, D.L., and Wilson, G.L. Streptozotocin-induced alterations in the levels of functional mitochondrial anion transport proteins. Arch. Biochem. Biophys. 280:181-191 (1990).

Schaffer, S.W., Seyed Mozaffari, M., Artman, M., and Wilson, G.L. Basis for the systolic and diastolic defects associated with noninsulin dependent diabetes mellitus. Am. J. Physiol. 256: E25 E30 (1989).

Mozaffari, M.S., Wilson, G.L., and Schaffer, S.W. Effect of chronic sulfonylurea treatment on the myocardium of insulin dependent diabetic rats. Can. J. Physiol. Pharmacol. 66: 1481 1486 (1988).

LeDoux, S.P., Hall, C.R., Forbes, P.M., Patton, N.J., and Wilson, G.L. Mechanisms of nicotinamide and thymidine protection from alloxan and streptozotocin toxicity. Diabetes 37: 1015 1019 (1988).

Wilson, G.L., Hartig, P.C., Patton, N.J., and LeDoux, S.P. Mechanisms of nitrosourea induced beta cell damange: activation of poly (ADP ribose) synthetase and cellular distribution. Diabetes 37: 213 216 (1988).

Gaines, K.L., Kayes, S.G., and Wilson, G.L. Factors affecting the infection of the D variant of encephalomyocarditis virus in the beta cells of C57BL/6J mice. Diabetologia 30: 419 425 (1987).

Gaines, K.L., Kayes, S.G., and Wilson, G.L. Altered pathogenesis in encephalomyocarditis virus (D Variant) infected diabetes susceptible and resistant strains of mice. Diabetologia 29: 313 320 (1986).

LeDoux, S.P., Woodley, S.E., Patton, N.J., and Wilson, G.L. Mechanisms of nitrosourea induced beta cell damage: alteractions in DNA. Diabetes 35: 866 872 (1986).

Mossman, B.T., Ireland, C.M., LeDoux, S., and Wilson, G.L. Comparative interactions of streptozotocin and chlorozotocin with DNA of an insulin secreting cell line (RINr). Diabetologia 29: 186 191 (1986).

Schaffer, S.W., Seyed Mozaffari, M., Cutcliff, C.R., and Wilson, G.L. A postreceptor myocardial metabolic defect in a rat model of non insulin dependent diabetes mellitus. Diabetes 35: 593 597 (1986).

Mossman, B.T., Wilson, G.L., Ireland, C., and Craighead, J.E. Chlorozotocin: a diabetogenic analog of streptozotocin with dissimilar mechanisms of action on pancreatic beta cells. Diabetes 34: 602 610 (1985).

Bernacki, R.J., Wilson, G.L., Mossman, B.T., Angelino, N., and Korytnyk, W. The therapeutic and diabetogenic potential of two newly synthesized nitrosoureido sugars. Cancer Res. 45: 695 7021 (1985).

Schaffer, S.W., Tan, B.H., and Wilson, G.L. Development of a cardiomyopathy in a model of non insulin dependent diabetes. Am. J. Physiol. 248: H179 H185 (1985).

Wilson, G.L., Patton, N.J., McCord, J.M., Mullins, D.W., and Mossman, B.T. Mechanisms of streptozotocin and alloxan induced damage in rat B cells. Diabetologia 27: 587 591 (1984).

Tan, B.H., Wilson, G.L., and Schaffer, S.W. Effect of tolbutamide on myocardial metabolism and mechanical performance of the diabetic rat. Diabetes 33: 1138 1143 (1984).

LeDoux, S.P., and Wilson, G.L. Effects of streptozotocin on a clonal isolate of rat insulinoma cells. Biochem. Biophys. Acta 804: 387 392 (1984).

Wilson, G.L., and Gaines, K.L. Effects of the rodenticide vacor on cultured rat pancreatic beta cells. Toxicol. Appl. Pharmacol. 68: 375 379 (1983).

Palmer, G.C., Wilson, G.L., and Chronister, R.B. Streptozotocin induced diabetes produces alterations in adenylate cyclase in rat cerebrum, cerebral microvessels and retina. Life Sciences 32: 365 374 (1983).

Wilson, G.L., Mossman, B.T., and Craighead, J.E. Use of pancreatic beta cells in culture to identify diabetogenic N nitroso compounds. In Vitro 19: 25 30 (1983).

Wilson, G.L., Bellomo, S.C., and Craighead, J.E. Effect on interferon on encephalomyocarditis virus infection of cultured mouse pancreatic beta cells. Diabetologia 24: 38 41 (1983).

D'Andrea, B.J., Wilson, G.L., and Craighead, J.E. Effect of genetic obesity in mice on the induction of diabetes by encephalomyocarditis virus. Diabetes 30: 451 454 (1981).

Wilson, G.L., Appel, M.C., and Chick, W.L. Pancreatic islet cell monolayer cultures: immunoperoxidase staining and autoradiography. Tissue Culture Association Manual 5: 1193 1197 (1980).

Wilson, G.L., D'Andrea, B.J., Bellomo, S.C., and Craighead, J.E. Encephalomyocarditis virus infection of cultured pancreatic beta cells. Nature 285: 112 113 (1980).

Redman, H.C., Wilson, G.L., and Hogan, J.E. Effects of chlopromazine combined with intermittent light stimulation on the electroencephalogram and clinical response of the beagle dog. Am. J. Vet. Res. 34: 929 (1973).

Redman, H.C., Hogan, J.E., and Wilson, G.L. Effects of intermittent light stimulation singly and combined with pentylenetetrazol on the electroencephalogram and clinical response of the beagle dog. Am. J. Vet. Res. 33: 677 (1972).

BOOK CHAPTERS AND REVIEW ARTICLES

Dobson, A. W., Kelley M. R., Wilson, G.L., and LeDoux, S.P. Targeting DNA Repair Proteins to Mitochondria. In: Mitochondrial DNA; Methods and Protocols. (Ed. W.C. Copeland) Humans Press, pp.351-362 (2002).

Longnecker, D.S., and Wilson, G.L. Pancreas. In: Fundamentals of Toxicologic Pathology, Second Edition, Volume 2, (W. Haschek and C. Rousseaux, Eds.) Academic Press, San Diego (2002).

Rodriguez, H., Akman S.A., Holmquist, G.P., Wilson, G.L., Driggers, W.J., and LeDoux, S.P. Mapping oxidative DNA damage using ligation-mediated polymerase chain reaction technology. Methods 22:148-156 (2000).

LeDoux, S.P., Driggers W.J., Hollensworth, B.S., and Wilson, G.L. Repair of alkylation and oxidative damage in mitochondrial DNA. Mutat. Res. 434:149-159 (1999).

Wilson, G.L., and Longnecker, D.S. Pancreatic Toxicology. In: Endocrine and Hormonal Toxicology (P.W. Harvey, K.C. Rush, and A. Cockburn, Eds.) John Wiley & Sons Ltd., pp.125-153 (1999).

Liebler, D.C., Aust, A.E., Wilson, G.L., and Copeland, E.S. (Eds.), Workshop Report from the Division of Research Grants, National Institutes of Health: Reactive Oxidants from Nitric Oxide, Stress Responses and Cellular Signalling, and Repair of Oxidative DNA Damage: A Chemical Pathology Study Section Workshop. Molec. Carc. 22:209-220 (1998).

LeDoux, S.P., Wilson, G.L., and Bohr, V.A. Mitochondrial DNA Repair and Cell Injury. In: Mitochondrial Dysfunction (D.P. Jones and L.H. Lash, Eds.) Academic Press, San Diego, pp. 461-476 (1993).

Wilson, G.L., and LeDoux, S.P. Interactions of Chemicals with Pancreatic B-cells. In: Lessons from Animal Diabetes IV (E. Shafrir, Ed.) Smith-Gordon, London, pp. 17-26 (1993).

Schaffer, S.W., Allo, S., and Wilson, G.L. Abnormal Phosphorylation: Cause of Reduced Responsiveness to Isoproterenol. In: Cardiovascular Disease In Diabetes (M. Nagano, S. Mochizuki and N.S. Dhalla, Eds.) Kluwer Academic Publishers, Norwell, Massachusetts, pp. 199-210 (1992).

Longnecker, D.S., and Wilson, G.L. Pancreas. In: Fundamentals of Toxicologic Pathology (W. Haschek and C. Rousseaux, Eds.) Academic Press, San Diego, pp. 254-277 (1991).

Wilson, G.L., and Leiter, E.H. Streptozotocin Interactions with Pancreatic Cells and the Induction of Insulin Dependent Diabetes. In: The Role of Viruses and the Immune System In Diabetes Mellitus Experimental Models (T. Dyrberg, Ed.) Springer Verlag, Berlin, pp. 27-54 (1990).

Wilson, G.L., and LeDoux, S.P. The Role of Chemicals in the Etiology of Diabetes Mellitus. Toxicol. Path. 17:357-363 (1989).

Leiter, E.H., and Wilson, G.L. Viral Interactions with Pancreatic Beta Cells. In: Pathology of the Endocrine Pancreas in Diabetes (D. Pipeleers and J. Wieczorek, Eds.) Springer Verlag, Heidelberg, pp. 85 105 (1988).

Schaffer, S.W., Artman, M.F., and Wilson, G.L. Properties of Insulin Dependent and Noninsulin Dependent Diabetic Cardiomyopathies. In: Pathogenesis of Myocarditis and Cardiomyopathy: Recent Experimental and Clinical Studies (Sakiguchi, M., Kawai, C. and Abelmann, W., Eds.) University of Tokyo Press, Tokyo, Japan, pp. 149 162 (1987).

Wilson, G.L. Factors Affecting Insulin Secretion. Cellular Engineering Newsletter Oct/Nov: 3 5 (1983).

Craighead, J.E., MacPherson, B.R., Wilson, G.L., D'Andrea, B.J., and Chates, M.W. Viral Diabetes: Factors Influencing the Severity of the Insular Lesion in Experimental Murine Diabetes Mellitus. In: Etiology and Pathogenesis of Insulin Dependent Diabetes Mellitus (J.M. Martin, R.M. Ehrlich and F.J. Holland, Eds.) Raven Press, New York, pp. 73 77 (1981).

Wilson, G.L. Functional Analysis of Rabbit Pancreatic Cells In Vitro. Ph.D. Thesis, University of Illinois at the Medical Center, University Microfilms, Ann Arbor, Michigan (1976).

SELECTED ABSTRACTS

Ho R, Rachek LI, Yi X, Kelley MR, LeDoux SP, Wilson GL. Mitochondrial Targeting of Yeast Apn1 Alters DNA Repair Capacity in a Neuronal Cell Line. Proceedings of the American Association for Cancer Research 44; 1435, 2003.

Rachek LI, Alexeyev M, Pasurkh V, LeDoux SP, Wilson GL. Tet-regulated Targeting of Endonuclease VIII into Mitochondria. Proceedings of the American Association for Cancer Research 44; 1435, 2003.

Druzhyna, N.M., Hollensworth, B.S., Kelley, M.R., Wilson, G.L., and LeDoux, S.L. Targeting the human 8-oxoguanine DNA glycosylase repair enzyme to mitochondria of oligodendrocytes protect cells against menadione-induced oxidative stress. Proceedings American Association for Cancer Research 43:300 (2002).

Grishko, V.I., LeDoux, S.P., and Wilson, G.L. Free fatty acids induce mitochondrial DNA damage in RINr38 rat insulinoma cells. Proceedings American Association for Cancer Research 43:347 (2002).

Ho, R., Xu, Y., Kelley, M.R., LeDoux, S.P., and Wilson, G.L. Mitochondrial targeting of the AP endonuclease APN-1 to cells and its effect on DNA repair. Proceedings American Association for Cancer Research 43:637 (2002).

Harrison, J.F., Wilson, G., and LeDoux, S.P. The role of APE in cellular resistance to DNA-damaging and anti-cancer agents in CNS cells. Proceedings American Association for Cancer Research 43:798 (2002).

Shokolenko, I.N., Alexeyev, M.F., LeDoux, S.P., and Wilson, G.L. Delivery of green cluorescent protein into breast cancer cells via protein transduction. Proceedings American Association for Cancer Research 43:804 (2002).

Rachek, L.I., LeDoux, S.P., and Wilson, G.L. Tc-mediated expression of hOGG1 in mitochondria. Proceedings American Association for Cancer Research 43:827 (2002).

V. Grishko, M. Solomon, S.P. LeDoux, G.L. Wilson, and M.N. Gillespie. Xanthine Oxidase (XO)-Induced Mitochondrial(mt) DNA Damage in Pulmonary Vascular Endothelial Cells (Ecs) Mapped at Nucleotide Resolution. Free Radical Biology and Medicine 27 Supplement S105 (1999).

B.S. Hollensworth, C. Shen, G.L. Wilson, and S.P. LeDoux. Menadione-Induced Apoptosis in CNS Cells Involves Cytochrome C Release and Caspase-9 Activation. Free Radical Biology and Medicine 27 Supplement S140 (1999).

A.W. Dobson, Y. Xu, M.R. Kelly, S.P. LeDoux, and G.L. Wilson. Enhanced mtDNA Repair and Clonogenic Survival by Targeting the OGG1 Repair Enzyme to Mitochondria. Free Radical Biology and Medicine 27 Supplement S153 (1999).

A.W. Dobson, Y. Xu, M.R. Kelly, S.P. LeDoux, and G.L. Wilson. Targeting of DNA Repair Enzymes to Mitochondria. AACR Proc. 40:4275 (1999).

N. Druzhyna, M.E. Smulson, S.P. LeDoux, and G.L. Wilson. Poly (ADP-ribose) Polymerase Facilitates the Repair of N-methylpurines in mtDNA. AACR Proceedings 40:1042 (1999).

V. Grishko, D.R. Spitz, G.L. Wilson, and S.P. LeDoux. Role of Mitochondrial DNA Damage and Repair in Resistance to Oxidative Damage. AACR Proceedings 40:3814 (1999).

S. Hollensworth, C. Shen, T. Hazra, T. Izumi, G. Wilson, and S.P. LeDoux. Increased mtDNA Repair Capacity in CNS Cells Is Due to Higher Mitochondrial Levels of Repair Enzymes. AACR Proceedings 40:4889 (1999).

I. Shokolenko, S.P. LeDoux, G.L. Wilson T.M. Oberyszyn, and F.M. Roberson. Damage to Mitochondrial DNA by Nitric Oxide in Human Keratinocytes. AACR Proceedings 40:4885 (1999).

Grishko, V.I., LeDoux, S.P., and Wilson, G.L. Mapping of mitochondrial DNA damage following exposure to nitric oxide using ligation-mediated PCR. AACR Proceedings 39:1629 (1998).

Dudek, E.J., Dobson, A.W., LeDoux, S.P., Wilson, G.L., Martin, B.D., Hamilton, J.W., and Wetterhahn, K.E. Chromium (VI) induces specific types of mitochondrial DNA damage in human lung A549 cells. AACR Proceedings 39:1640 (1998).

Dobson, A.W., LeDoux, S.P., and Wilson, G.L. Oxidative damage to mitochondrial DNA in Cockayne syndrome cells. AACR Proceedings 39:1641 (1998).

Driggers, W., LeDoux, S.P., and Wilson, G.L. Removal of oxidative and alkylation damage from the mitochondrial DNA of a Xeroderma pigmentosum group A human fibroblast cell line. AACR Proceedings 39:1642 (1998).

Druzhyna, N.N., LeDoux, S.P., and Wilson, G.L. Damage and repair of mitochondrial DNA following exposure to nitric oxide. AACR Proceedings 39:1643 (1998).

Hollensworth, S.B., Shen, C., Wilson, G.L., and LeDoux, S.P. Neurons show decreased repair of oxidative damage to mitochondrial DNA compared to CNS glial cells. AACR Proceedings 39:1644 (1998).

Robertson, F.M., D’Ambrosio, S.M., Oberyszyn, T.M., Tong, H.H., Grishko, V.I., LeDoux, S.P., and Wilson, G.L. Cytotoxicity and DNA damage in cultured human epidermal keratinocytes induced by nitric oxide, peroxynitrite, and H2O2. Am. Assoc. Cancer Res. 38:881 (1997).

Druzhyna, N., Nair, R.G., LeDoux, S.P., and Wilson, G.L. Defective repair of oxidative damage mitochondrial DNA in Down’s syndrome. Am. Assoc. Cancer Res. 38:880 (1997).

Grishko, V., Driggers, W., LeDoux, S., and Wilson, G. Detection of alkylation damage in mitochondrial DNA at the nucleotide level using ligation-mediated polymerase chain reaction. Am. Assoc. Cancer Res. 38:2249 (1997).

Hollensworth, S., Shen, C., Wilson, G., and LeDoux, S.P. Glial cell-specific differences in induction of apoptosis by DNA damaging agents. Am. Assoc. Cancer Res. 38:276 (1997).

Driggers, W.J., Grishko, V.I., Holmquist, G.P. LeDoux, S.P., and Wilson, G.L., Detection of oxidative damage and subsequent repair in mitochondrial DNA at the nucleotide level using ligation-mediated polymerase chain reactions. Am. Assoc. Cancer Res. 37:853 (1996).

Grishko, V.I., Druzhina, N., Patton, N.J., LeDoux, S.P., and Wilson, G.L., Mitochondrial DNA is damaged by nitric oxide. Am. Assoc. Cancer Res. 37:852 (1996).

Hollensworth, S., Shen, C., Wilson, G., and LeDoux, S.P. Repair of oxidative damage in mitochondrial DNA of astrocytes and oligodendrocytes. Am. Assoc. Cancer Res. 37:851 (1996).

LeDoux, S.P., Williams, B.A., Shen, C., Thomale, J. Rajewsky, M.F., and Wilson, G.L. Glial cell-specific differences in repair of O6-methylguanine. Am. Assoc. Cancer Res. 37:850 (1996).

LeDoux, S.P., Shen, C.C., and Wilson, G.L. Mitochondrial DNA repair of alkali-labile sites in cultured oligodendrocytes from the CNS. Am. Assoc. Cancer Res. 36:836 (1995).

Grishko, V., Driggers, W., LeDoux, S.P., and Wilson, G.L. Repair of oxidative damage in specific nuclear sequences. Am. Assoc. Cancer Res. 36:835 (1995).

Driggers, W., Grishko, V., LeDoux, S.P., and Wilson, G.L. Repair of oxidative damage in the mitochondrial DNA of normal and xeroderma pigmentosum Group A human fibroblast cell lines. Am. Assoc. Cancer Res. 36:834 (1995).

LeDoux, S.P., Nelson, J.W., and Wilson, G.L. Repair of a naturally occurring mutagenic lesion in ß-cells. Diabetes 43:127A (1994).

Ray, L.S., LeDoux, S.P., and Wilson, G.L. Poly (ADP-ribose) polymerase activity is required for efficient mitochondrial DNA repair. Diabetes 43:11A (1994).

Ray, L.S., Boroughs IV, A.R., LeDoux, S.P., and Wilson, G.L. Efficient mitochondrial DNA repair in a cell line deficient in alpha and/or delta DNA polymerase (V79/UC). Proc. Am. Assn. Cancer Res. 35:3199 (1994).

Driggers, W.J., LeDoux, S.P., and Wilson, G.L. Strand specific repair of oxidative damage in mitochondrial DNA of RINr 38 cells. Proc. Am. Assn. Cancer Res. 35:3198 (1994).

Driggers, W.J., LeDoux, S.P., and Wilson, G.L. Repair of oxygen free-radical induced DNA damage in the RINr cell mitochondrial genome. Proc. Am. Assn. Cancer Res. 34:34 (1993).

Ray, L.S., Baggette, K.D., Chatterjee, S., Berger, N.A., LeDoux, S.P., and Wilson, G.L. A cell line deficient in poly (ADP-ribose) synthetase (ADPRT 351) is deficient in repair of N-methylpurines in mitochondrial DNA. Proc. Am. Assn. Cancer Res. 34:33 (1993).

Wilson, G.L., and Goodman, S.R. Spectrin in pancreatic beta cells. Diabetes 41:148A (1992).

Nelson, J.W., LeDoux, S.P., and Wilson, G.L. Induction of O6-methylguanine-DNA- methyltransferase mRNA expression in Rat Pancreatic Beta Cells. Proc. Am. Assn. Cancer Res. 33:865 (1992).

LeDoux, S.P., Patton, N.J., and Wilson, G.L. Repair of alkali-labile sites within mitochondrial DNA of XPD cells. Proc. Am. Assn. Cancer Res. 33:48 (1992).

Ray, L. Perakslis, E. LeDoux, S., and Wilson, G. Effect of inhibition of poly (ADP-ribose) synthetase on repair of alkali-labile sites within mitochondrial DNA. Proc. Am. Assn. Cancer Res. 33:47 (1992).

Nelson, J.W., LeDoux, S.P., and Wilson, G.L. Repair of the DNA lesion O6-methylguanine in pancreatic beta cells. Proc. Am. Assn. Cancer Res. 32:35 (1991).

Pettepher, C., LeDoux, S., Wilson, G., Beecham, J. Stevnsner, T., and Bohr, V. Repair of alkali labile sites within mitochondrial DNA. Proc. Am. Assn. Cancer Res. 32:48 (1991).

Kaplan, R.S., Mayor, J.A., Blackwell, R., Maughon, R.H., and Wilson, G.L. Effect of insulin supplementation on diabetes-induced alterations in mitochondrial anion transport function. Biophys. J. 59:136a (1991).

Kaplan, R.S., Oliveira, D.L., and Wilson, G.L. Effects of diabetes on mitochondrial anion transporters. FASEB 4:A1966 (1990).

Wilson, G., LeDoux, S., and Bohr, V. Preferential repair in an actively transcribed gene. Proc. Am. Assn. Cancer Res. 31:4 (1990).

LeDoux, S., Wilson, G., and Bohr, V. Preferential repair of alkali labile sites within the insulin gene. Proc. Am. Assn. Cancer Res. 31:4 (1990).

Pettepher, C., LeDoux, S., and Wilson, G. Assessment of alkylation damage and repair within the mitochondrial DNA for RINr 38 cells. Diabetes 39:274A (1990).

Nelson, J.W., LeDoux, S., and Wilson, G. Repair of the cytotoxic and mutagenic DNA lesion O6-alkylguanine in ß cells. Diabetes 39:218A (1990).

LeDoux, S., and Wilson, G. Repair of alkylation damage within the insulin gene. Diabetes 37: 159A (1988).

Schaffer, S.W., Allo, S., and Wilson, G. Abnormal calcium movement in noninsulin dependent diabetic cardiomyopathy. Diabetes 37:234A (1988).

Wilson, G.L., Woodley, S.E., and Ledoux, S.P. 32P endlabeling of DNA adducts formed by streptozotocin and methylnitrosourea in insulin secreting pancreatic beta cells. J. Cell. Biochem. 12A:E173 (1988).

LeDoux, S.P., Bohr, V.A., and Wilson, G.L. Repair of alylation damage in specific DNA sequences. J. Cell. Biochem. 12A:E231 (1988).

LeDoux, S., and Wilson, G. Mechanisms of protection from alloxan and streptozotocin toxicity by nicotinamide and thymidine. Diabetes 36:170A (1987).

Wilson, G., Hartig, P., and LeDoux, S. Unique sequestering of streptozotocin by beta cells. Diabetes 36:190A (1987).

Gaines, K.L., and Wilson, G.L. Factors affecting the infection of encephalomyocarditis virus in the beta cells of C57BL/6J mice. Diabetes 35:70A (1986).

LeDoux, S.P., and Wilson, G.L. Alteration of beta cell DNA by streptozotocin and MNU. Diabetes 35:174A (1986).

Gaines, K.L., and Wilson, G.L. Factors affecting the tropism of the D variant of EMC virus. Diabetes 34:135A (1985).

LeDoux, S.P., and Wilson, G.L. Comparison of streptozotocin and MNU induced DNA damage in cultured rat beta cells. Diabetes 34:183A (1985).

Gaines, K.L., Kayes, S.G., and Wilson, G.L. EMC virus infection in diabetes susceptible and resistant mice. Diabetes 33:38a (1984).

LeDoux, S.P., and Wilson, G.L. Effects of streptozotocin on normal and neoplastic beta cells. Diabetes 133:51a (1984).

Gaines, K.L., Mossman, B.T., and Wilson, G.L. Effects of the rodenticide vacor on cultured rat pancreatic beta cells. Anat. Rec. 205:59A (1983).

Wilson, G.L., and Mossman, B.T. Assessment of the mechanisms of action of various beta cell toxins. Diabetes 32:108A (1983).

Wilson, G.L., and Mossman, B.T. Diabetogenic effects of various nitrosoamides on pancreatic beta cells In Vitro. Diabetes 31:100A (1982).

Palmer, G.C., Wilson, G.L., Palmer, S.J., and Chronister, R.B. Streptozotocin induced diabetes influences receptor activation of adenylate cyclase in rat retina, microvessels, cerebrum and pia arachnoid. Fed. Proc. 41:1227A (1982).

Mossman, B.T., Wilson, G.L., and Craighead, J.E. Chlorozotocin is diabetogenic in hamsters and mice. Proc. Am. Assn. Cancer Res. 22:235A (1981).

Wilson, G.L., Mossman, B.T., and Craighead, J.E. Diabetogenic effects of chlorozotocin on murine pancreatic beta cells In Vitro and In Vivo. Cell Biol. 87:327 (1980).

D'Andrea, B.J., Craighead, J.E., and Wilson, G.L. Metabolic influences on susceptibility of C57BL16 (ob/ob) mice to encephalomyocarditis viral diabetes Diabetes 29:116A (1980).

Wilson, G.L., Bellomo, S., Bonazinga, P., and Craighead, J.E. Interferon effect on encephalomyocarditis virus infection of cultured mouse pancreatic beta cells. Diabetes 29:83A (1980).

Clark, W.A., Wilson, G.L., and Rafferty, K.A. Quantitation of myoblast precursors in adult mammalian skeletal muscle by In Vitro clonal analysis. Cell Biol. 67:71 (1975).

Wilson, G.L. Amylase production by pancreatic epithelial cells In Vitro. Anat. Rec. 181:510 (1975).

INVITED PRESENTATIONS

April 2003 Mitochondrial DNA Repair, Institute of Environmental Health Sciences, Wayne State University, Detroit, MI.

February 2003 Mitochondrial DNA and Diabetes, Surgery Grand Rounds, University of South Alabama, Mobile, AL.

January 2001 Mammalian DNA Repair, Gordon Conference, Ventura, CA.

October 2000 Mitochondrial DNA Repair? Surely You are Joking Dr. Wilson. NIEHS Toxicology Center, Oregon State University, Corvalis, OR.

April 2000 Factors Influencing Mitochondrial DNA Repair. Cancer Center, Ohio State University, Columbus, OH.

January 1999 Neurons Show Decreased Repair of Oxidative Damage to Mitochondrial DNA Compared to CNS Glial Cells. Mammalian DNA Repair Gordon Res. Conf., Ventura, CA .

January 1999 Mitochondrial DNA Repair, University of Indiana Cancer Center, Indianapolis, Indiana.

August 1998 Strategy for Identification of Non-Viral Environmental Factors: Toxins. Workshop on Environmental Etiology of Type 1 Diabetes: Viruses and Other Factors. Sponsored by the National Institutes of Health and the Juvenile Diabetes Foundation, Washington D.C.

April 1997 Repair of Oxidative Damage in Mitochondrial DNA. Symposium: Oxidative Mechanisms of Cell Signaling and Repair in Disease, FASEBMeetings, New Orleans, Louisiana.

March 1997 DNA Repair in the Mitochondrion, Department of Pathology, New Jersey Medical School, Newark, New Jersey.

March 1997 The Other DNA, New York University, Department of Environmental Medicine, Tuxedo, New York.

February 1997 Nitric Oxide-Induced Damage in Mitochondrial DNA, Workshop on Nitric Oxide for the Chemical Pathology Study Section, Ventura, California.

February 1997 Repair of Oxidative Damage in Mitochondrial DNA, DNA Repair Gordon Conference, Ventura, California.

December 1995 Sequence Specific DNA Repair, Center for Toxicology, University of Arizona, Tucson, Arizona.

October 1995 DNA Repair: From the Nucleus to the Mitochondria, Surgery Grand Rounds, Department of Surgery, University of South Alabama, Mobile, Alabama.

September 1993 Repair of Specific Nuclear and Mitochondrial DNA Sequences, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.

May 1993 DNA Repair: From the Nucleus to the Mitochondria, Department of Radiology, Ohio State University, Columbus, Ohio.

April 1993 A Preference for DNA Repair, Department of Pharmacology, State University of New York, Stony Brook, New York.

June 1990 Repair of Alkylation Damage in the Insulin Gene, Jackson Laboratory, Bar Harbor, Maine.

March 1990 Environmental Etiologies of Diabetes Mellitus, Medical Grand Rounds, Department of Internal Medicine, University of South Alabama, Mobile, Alabama.

July 1989 Mechanisms of Action of Various Diabetogenic Nitrosoamides, Gordon Research Conference: Mechanisms of Toxicity, Kimball Union Academy, Meriden, New Hampshire.

June 1988 The Role of Chemicals in the Etiology of Diabetes Mellitus, VII International Symposium of the Society of Toxicological Pathologists, Boston, Massachusetts.

January 1988 32P Endlabeling of DNA Adducts Formed by Streptozotocin and Methy Initrosourea in Insulin Secreting Cells, UCLA Symposium: Mechanisms and Consequences of DNA Damage Processing, Taos, New Mexico.

June 1987 Environmental Etiologies of Diabetes Mellitus, Department of Pathology, University of Vermont, Burlington, Vermont.

June 1986 Convener: Round Table on Cells Derived from Pancreatic Tissue, 37th Annual Meeting of the Tissue Culture Association, Chicago, Illinois.

September 1985 Use of Monolayer Cultures of Pancreatic Islet Cells to Study Environmental Diabetogens, Third International Cell Culture Congress, Sendai, Japan.

September 1985 DNA Damage and Repair in Pancreatic Beta Cells, Symposium on the Culture and Transplantation of Pancreatic Islet Cells, Oita, Japan.

April 1985 Chemically Induced Diabetes Mellitus, Endocrinology Research and Training Center, Baylor College of Medicine, Houston, Texas.

April 1985 Chemically Induced Diabetes Mellitus, Diabetes Research and Training Center, University of Virginia, College of Medicine, Charlottesville, Virginia.

July 1983 Use of Cultured Beta Cells to Identify Diabetogenic Toxins, Department of Medicine, University of Nevada, Reno, Nevada.

May 1983 Factors Affecting EMC Virus-Induced Diabetes, Department of Pathology, University of Vermont, Burlington, Vermont.

October 1982 Chlorozotocin-Induced Beta Cell Damage, Juvenile Diabetes Foundation Workshop on Mechanisms of Beta Cell Injury, Scanticon Conference Center, Princeton, New Jersey.

December 1981 Chemically-Induced Diabetes Mellitus, Department of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo, New York.