Table 3. Size of Left Ventricle, Risk Region, and Infarct
|
Heart |
LV |
Risk
Region |
Infarct |
Risk Region |
Infarct |
Infarct |
|
(mg) |
(mg) |
(mg) |
(mg) |
(% of LV) |
(% of risk region) |
(% of LV) |
|
|
|
|
|
|
|
|
Group I |
209.4±6.1 |
148.4±5.6 |
46.9±4.1 |
24.0±2.7§= |
31.6±2.7 |
50.9±2.6== |
16.0±1.5*# |
Group II |
153.7±4.9 |
110.9±4.2 |
45.3±3.3 |
24.2±2.5§= |
41.0±2.9 |
53.2±3.6== |
22.1±2.4*# |
Group III |
159.5±9.4 |
116.5±7.9 |
50.4±4.0 |
28.5±2.8§= |
43.8±3.1 |
56.7±2.4== |
24.6±2.1*# |
Group IV |
144.5±4.1 |
105.7±2.6 |
51.4±3.7 |
17.7±1.5*# |
49.3±4.0 |
14.2±1.9*# |
17.4±1.5*# |
Group V |
195.1±6.3 |
130.6±4.3 |
46.3±4.0 |
23.8±3.3=§ |
35.8±3.0 |
49.4±3.4=§ |
18.0±2.3=§ |
Group VI |
192.7±8.7 |
132.9±4.7 |
49.9±5.3 |
11.1±1.9=‡ |
38.4±4.2 |
22.2±2.6=‡ |
18.7±1.6=‡§ |
Group VII |
141.5±7.2 |
101.4±5.8 |
40.0±5.7 |
20.2±3.3=§ |
39.3±4.7 |
49.9±4.0=§ |
19.9±3.1=§ # |
Group VIII |
159.6±5.6 |
115.7±4.1 |
48.3±4.2 |
11.5±1.4#§ |
41.8±3.4 |
25.9±3.3#§= |
10.0±1.0#§# |
Mice in group I (control group, 4-h reperfusion; n=9)
underwent a 30-min coronary occlusion followed by 4 h of reperfusion. Mice in group II (control group, 24-h
reperfusion; n=14) underwent a 30-min coronary occlusion followed by 24 h of
reperfusion. In group III (early PC
sham group, n=11), the chest was opened for 1 h before a 30-min coronary
occlusion followed by 24 h of reperfusion (the 1 h of open-chest state
corresponded to the time interval necessary to perform the six
occlusion/reperfusion cycles in group IV).
Mice in group IV (early PC group, n=12) were preconditioned with a
sequence of six 4-min coronary occlusion /4-min reperfusion cycles; 10 min
later, they underwent a 30-min coronary occlusion followed by 24 h of
reperfusion. Mice in groups V and VII
(late PC sham group, 4-h and 24-h reperfusion; n=13 and 6, respectively)
underwent a thoracotomy and 1 h of open-chest state (without coronary
occlusion) on day 1 (the 1 h of open-chest state corresponded to the time
interval necessary to perform the six occlusion/reperfusion cycles in groups VI
and VIII); 24 h later (on day 2), they underwent a 30-min occlusion followed by
4 h (group V) or 24 h (group VII) of reperfusion. Mice in group VI (late PC group, 4-h reperfusion; n=14) were
preconditioned with a sequence of six 4-min occlusion/4-min reperfusion cycles
on day 1; on day 2, they were subjected to a 30-min occlusion followed by 4 h
of reperfusion. Mice in group VIII
(late PC group, 24-h reperfusion; n=13) were preconditioned with a sequence of
six 4-min occlusion/4-min reperfusion cycles on day 1; on day 2, they underwent
a 30-min coronary occlusion followed by 24 h of reperfusion. LV, left ventricle; Heart, total heart
weight (ventricles and atria). Data are
means ± SEM.
*P<0.05 vs. group III; #P<0.05 vs. group
II; =P<0.05 vs. group V; ‡P<0.05 vs. group I; §P<0.05
vs. group VII.
Reproduced from Ref. 2 with permission.